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Figure 3 | Journal of Ovarian Research

Figure 3

From: PRIMA-1 increases cisplatin sensitivity in chemoresistant ovarian cancer cells with p53 mutation: a requirement for Akt down-regulation

Figure 3

PRIMA-1-facilitated CDDP-induced apoptosis in Akt down-regulated chemoresistant p53-mutant ovarian cancer cells is mediated by p53. Akt function was down-regulated by adenoviral DN-Akt infection (MOI = 40). Apoptotic rate was evaluated to determione whether p53 is involved in the synergistic effect of PRIMA-1 and CDDP following transfection with p53 or control siRNA. *** p<0.001 vs CDDP & DN-Akt; Results are expressed as mean ± SEM of three independent experiments

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Journal of Ovarian Research

ISSN: 1757-2215

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