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Table 3 8-OHdG alteration associated with overall survival of serous ovarian cancer patients (N = 72)

From: The significance of the alteration of 8-OHdG in serous ovarian carcinoma

Characteristic Univariate analysis p value Multivariate analysis p value
  HR 95 % CI   HR 95 % CI  
FIGO stage    
  I 1.00 Reference   1.00 Reference  
  II 1.42 0.68-6.25   1.21 0.43-8.02  
  III 6.78 1.66-18.41   2.25 1.24-6.08  
  IV 9.43 3.61-27.87 <0.01 3.28 1.47-9.54 <0.01
Grade 4.12 1.35-12.69 <0.01 2.57 1.62-3.45 <0.01
Suboptimal CRS 2.16 1.25-3.85 <0.01 1.65 1.19-2.55 0.02
Ascites 1.47 1.26-3.04 0.01 1.23 1.08-2.36 0.04
Nadir CA-125 level 1.02 1.01-1.04 <0.01 1.01 1.00-1.03 <0.01
p53 positive 1.30 1.09-4.39 0.02 1.13 0.96-2.41 0.10
8-OHdG (T/A) 1.35 1.13-3.42 <0.01 1.18 1.01-2.07 <0.01
hOGG1 protein (T/A) 0.84 0.78-1.06 0.54 0.89 0. 88–1.02 0.65
Age 1.01 1.00-1.01 0.04 1.00 0.98-1.01 0.21
  1. HR, Hazard ratio; CI, Confidence interval; CRS, Cytoreductive surgery. T/A, Tumor/Adjacent non-tumor tissue.