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Table 2 Summary of the IC 50 valuesM) and Resistance Factors (RF) for CS, CB, OX, CH1 and BORT as applied to the ovarian cancer cell lines A2780, A2780cisR, A2780ZD0473R and SKOV-3

From: Carboplatin and oxaliplatin in sequenced combination with bortezomib in ovarian tumour models

  A2780 A2780cisR RF A2780ZD0473R RF SKOV-3 RF
CS 0.5 ± 0.03 8.2 ± 0.6 17.7 6.0 ± 0.5 13.0 10.2 ± 0.5 22.2
CB 14.0 ± 1.4 48.9 ± 3.9 3.5 64.6 ± 3.2 4.6 43.4 ± 3.9 3.1
OX 0.2 ± 0.01 0.4 ± 0.02 1.9 0.4 ± 0.03 2.1 43.6 ± 3.0 229.4
CH1 21.3 ± 2.0 26.6 ± 1.9 1.2 25.4 ± 1.7 1.2 29.8 ± 1.8 1.4
BORT 0.05 ± 0.01 0.05 ± 0.01 1.0 0.04 ± 0.01 0.8 0.09 ± 0.01 1.8
  1. RF is defined as the ratio of the IC 50 value in the resistant cell line over that in the responsive parent cell line.