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Table 2 Summary of the IC 50 valuesM) and Resistance Factors (RF) for CS, CB, OX, CH1 and BORT as applied to the ovarian cancer cell lines A2780, A2780cisR, A2780ZD0473R and SKOV-3

From: Carboplatin and oxaliplatin in sequenced combination with bortezomib in ovarian tumour models

 

A2780

A2780cisR

RF

A2780ZD0473R

RF

SKOV-3

RF

CS

0.5 ± 0.03

8.2 ± 0.6

17.7

6.0 ± 0.5

13.0

10.2 ± 0.5

22.2

CB

14.0 ± 1.4

48.9 ± 3.9

3.5

64.6 ± 3.2

4.6

43.4 ± 3.9

3.1

OX

0.2 ± 0.01

0.4 ± 0.02

1.9

0.4 ± 0.03

2.1

43.6 ± 3.0

229.4

CH1

21.3 ± 2.0

26.6 ± 1.9

1.2

25.4 ± 1.7

1.2

29.8 ± 1.8

1.4

BORT

0.05 ± 0.01

0.05 ± 0.01

1.0

0.04 ± 0.01

0.8

0.09 ± 0.01

1.8

  1. RF is defined as the ratio of the IC 50 value in the resistant cell line over that in the responsive parent cell line.