Table 3 Significant GO terms and KEGG pathways of the 7 functional modules

Module 1

GOTERM_BP_FAT

GO:0000280~nuclear division

47

1.32E-63

GOTERM_BP_FAT

GO:0007067~mitosis

47

1.32E-63

GOTERM_BP_FAT

GO:0000087~M phase of mitotic cell cycle

47

3.30E-63

GOTERM_BP_FAT

GO:0048285~organelle fission

47

1.02E-62

GOTERM_BP_FAT

GO:0000279~M phase

48

7.59E-57

GOTERM_CC_FAT

GO:0000775~chromosome, centromeric region

62

8.67E-113

GOTERM_CC_FAT

GO:0000776~kinetochore

50

9.99E-95

GOTERM_CC_FAT

GO:0000779~condensed chromosome, centromeric region

47

4.45E-91

GOTERM_CC_FAT

GO:0000777~condensed chromosome kinetochore

44

2.07E-86

GOTERM_CC_FAT

GO:0044427~chromosomal part

62

3.37E-77

GOTERM_MF_FAT

GO:0008017~microtubule binding

10

2.56E-09

GOTERM_MF_FAT

GO:0015631~tubulin binding

10

5.32E-08

GOTERM_MF_FAT

GO:0051010~microtubule plus-end binding

5

5.00E-06

GOTERM_MF_FAT

GO:0043515~kinetochore binding

4

1.77E-04

GOTERM_MF_FAT

GO:0003777~microtubule motor activity

6

0.00746240

KEGG_PATHWAY

hsa041114:Oocyte meiosis

7

1.62E-04

KEGG_PATHWAY

hsa04110:Cell cycle

7

3.48E-04

Module 2

GOTERM_BP_FAT

GO:0005250~DNA replication

33

1.90E-52

GOTERM_BP_FAT

GO:0006259~DNA metabolic process

34

2.23E-40

GOTERM_BP_FAT

GO:0006261~DNA-dependent DNA replication

17

2.18E-26

GOTERM_BP_FAT

GO:0006270~DNA replication initiation

12

7.20E-23

GOTERM_BP_FAT

GO:0007049~cell cycle

17

6.59E-08

GOTERM_CC_FAT

GO:0005654~nucleoplasm

32

3.08E-30

GOTERM_CC_FAT

GO:0031981~nuclear lumen

32

1.62E-23

GOTERM_CC_FAT

GO:0070013~intracellular organelle lumen

32

8.91E-21

GOTERM_CC_FAT

GO:0043233~organelle lumen

32

1.80E-20

GOTERM_CC_FAT

GO:0031974~membrane-enclosed lumen

32

3.28E-20

GOTERM_MF_FAT

GO:0003677~DNA binding

26

6.52E-10

GOTERM_MF_FAT

GO:0003688~DNA replication origin binding

5

1.25E-06

GOTERM_MF_FAT

GO:0003697~single-stranded DNA binding

6

2.54E-04

GOTERM_MF_FAT

GO:0016779~nucleotidylt ransferase activity

6

0.01510849

GOTERM_MF_FAT

GO:0001882~nucleoside binding

15

0.01658336

KEGG_PATHWAY

hsa03030:DNA replication

16

2.19E-23

KEGG_PATHWAY

hsa04110:Cell cycle

19

1.62E-19

KEGG_PATHWAY

hsa03420:Nucleotide excision repair

6

0.00369525

Module 3

GOTERM_BP_FAT

GO:0008610~lipid biosynthetic process

17

1.55E-13

GOTERM_BP_FAT

GO:0008202~steroid metabolic process

13

1.63E-10

GOTERM_BP_FAT

GO:0006694~steroid biosynthetic process

10

1.46E-09

GOTERM_BP_FAT

GO:0055114~oxidation reduction

16

5.40E-08

GOTERM_BP_FAT

GO:0016125~sterol metabolic process

9

3.23E-07

GOTERM_CC_FAT

GO:0005783~endoplasmic reticulum

20

1.05E-10

GOTERM_CC_FAT

GO:0005829~cytosol

20

3.57E-08

GOTERM_CC_FAT

GO:0005789~endoplasmic reticulum membrane

10

1.70E-05

GOTERM_CC_FAT

GO:0042175~nuclear envelope-endoplasmic reticulum network

10

2.72E-05

GOTERM_CC_FAT

GO:0005792~microsome

9

1.12E-04

GOTERM_MF_FAT

GO:0008395~steroid hydroxylase activity

8

7.37E-12

GOTERM_MF_FAT

GO:0005506~iron ion binding

13

4.58E-08

GOTERM_MF_FAT

GO:0046027~phospholipid:diacylglycerol acyltransferase activity

5

3.56E-07

GOTERM_MF_FAT

GO:0016411~acylglycerol O-acyltransferase activity

6

5.50E-07

GOTERM_MF_FAT

GO:0020037~heme binding

9

2.00E-06

KEGG_PATHWAY

hsa00561:Glycerolipid metabolism

9

5.32E-07

KEGG_PATHWAY

hsa00120:Primary bile acid biosynthesis

7

6.29E-07

KEGG_PATHWAY

hsa00565:Ether lipid metabolism

8

2.94E-06

KEGG_PATHWAY

hsa00564:Glycerophospholipid metabolism

8

3.56E-04

Module 4

GOTERM_BP_FAT

GO:0007049~cell cycle

14

8.67 E-12

GOTERM_BP_FAT

GO:0051329~interphase of mitotic cell cycle

9

7.36E-11

GOTERM_BP_FAT

GO:0051325~interphase

9

9.31E-11

GOTERM_BP_FAT

GO:0000278~mitotic cell cycle

11

7.71E-10

GOTERM_BP_FAT

GO:0022402~cell cycle process

12

1.00E-09

GOTERM_CC_FAT

GO:0005654~nucleoplasm

10

4.75E-05

GOTERM_CC_FAT

GO:0031981~nuclear lumen

10

0.00340842

GOTERM_CC_FAT

GO:0070013~intracellular organelle lumen

10

0.01893931

GOTERM_CC_FAT

GO:0043233~organelle lumen

10

0.02288144

GOTERM_CC_FAT

GO:0031974~membrane-enclosed lumen

10

0.02691056

GOTERM_MF_FAT

GO:0016563~transcription activator activity

7

3.96E-04

KEGG_PATHWAY

hsa04110:Cell cycle

13

2.04 E-15

KEGG_PATHWAY

hsa05222:Small cell lung cancer

9

8.99E-09

KEGG_PATHWAY

hsa05200:Pathways in cancer

11

7.11E-07

KEGG_PATHWAY

hsa05220:Chronic myeloid leukemia

7

1.89E-05

KEGG_PATHWAY

hsa05215:Prostate cancer

7

5.34E-05

Module 6

GOTERM_BP_FAT

GO:0009511~response to wounding

9

7.88E-06

GOTERM_BP_FAT

GO:0042060~wound healing

5

0.03445470

GOTERM_CC_FAT

GO:0005576~extracellular region

13

2.43E-06

GOTERM_CC_FAT

GO:0005615~extracellular space

8

0.00156546

GOTERM_CC_FAT

GO:0044421~extracellular region part

8

0.01488625

GOTERM_MF_FAT

GO:0005520~insulin-like growth factor binding

4

0.00208348

GOTERM_MF_FAT

GO:0004252~serine-type endopeptidase activity

5

0.01598712

GOTERM_MF_FAT

GO:0008236~serine-type peptidase activity

5

0.02826126

GOTERM_MF_FAT

GO:0017171~serine hydrolase activity

5

0.02952737

KEGG_PATHWAY

hsa:04610:Complement and coagulation cascades

4

0.03363616

Module 7

GOTERM_BP_FAT

GO:0031145~anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process

15

1.37E-29

GOTERM_BP_FAT

GO:0051437~positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle

15

2.77E-29

GOTERM_BP_FAT

GO:0051443~positive regulation of ubiquitin-protein ligase activity

15

4.34E-29

GOTERM_BP_FAT

GO:0051439~regulation of ubiquitin-protein ligase activity during mitotic cell cycle

15

5.41E-29

GOTERM_BP_FAT

GO:0051351~positive regulation of ligase activity

15

8.31E-29

GOTERM_CC_FAT

GO:0005654~nucleoplasm

15

5.11E-13

GOTERM_CC_FAT

GO:0005829~cytosol

16

1.27E-12

GOTERM_CC_FAT

GO:0031981~nuclear lumen

15

5.65E-10

GOTERM_CC_FAT

GO:0005680~anaphase-promoting complex

6

1.60E-09

GOTERM_CC_FAT

GO:0000151~ubiquitin ligase complex

8

3.17E-09

GOTERM_MF_FAT

GO:0004842~ubiquitin-protein ligase activity

9

1.70E-12

GOTERM_MF_FAT

GO:0019787~small conjugating protein ligase activity

9

4.54E-12

GOTERM_MF_FAT

GO:0016881~acid-amino acid ligase activity

9

2.17E-11

GOTERM_MF_FAT

GO:0016879~ligase activity, forming carbon-nitrogen bonds

9

6.71E-11

KEGG_PATHWAY

hsa04120:Ubiquitin mediated proteolysis

14

9.66E-17

KEGG_PATHWAY

hsa04114:Oocyte meiosis

13

1.07E-15

KEGG_PATHWAY

hsa04110:Cell cycle

13

5.29E-15

KEGG_PATHWAY

hsa04914:Progesterone-mediated oocyte maturation

12

9.39E-15