Figure 6

Proposed cascade of the mechanisms involved in PAF production by extracellular EGF in ovarian cancer cells. Extracellular EGF binds to the EGF-receptor (EGFR) and transactivates the PAFR. Activation of EGFR and PAFR stimulates the phosphorylation of Akt and ERK. Only the ERK pathway induces the phosphorylation of cPLA₂, the latter increases the production of PAF.