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Table 2 Sensitivity and specificity for different cut-off values

From: Preoperative HE4 and ROMA values do not improve the CA125 diagnostic value for borderline tumors of the ovary (BOT) – a study of the TOC Consortium

Biomarker Cut-off value Sensitivity (%) Specificity (%)
Premenopausal    
HE4 93 pM 50 92.9
CA125 18.5 U/ml 100 41.4
CA125 180 U/ml 40 96
ROMA 3.45% 100 22.2
ROMA 28.5% 40 92.9
Postmenopausal    
HE4 66 pM 90 62.7
HE4 79 pM 50 80.4
CA125 35 U/ml 60 90.2
CA125 60 U/ml 70 76.5
ROMA 16.2% 90 47.1
ROMA 34.9% 70 86.3
ROMABOT 8% 90 43.1
ROMABOT 16% 70 76.5