Table 3 Relationship between clinical phenotypes and genotypes of the IRS-2 Gly1057Asp polymorphism

Subjects (n)

68

101

Age (years)

30.0 ± 6.2

29.7 ± 6.0

0.688

Body weight (kg)

58.7 ± 13.4

61.3 ± 13.3

0.208

Body height (cm)

159.8 ± 5.3

160.1 ± 5.6

0.779

BMI (kg/m²)

23.0 ± 5.0

23.9 ± 4.8

0.219

Waist circumference (cm)

80.8 ± 12.1

86.2 ± 11.6

0.058

Systolic BP (mmHg)

113 ± 12

117 ± 15

0.055

Diastolic BP (mmHg)

69 ± 10

71 ± 11

0.209

Total cholesterol (mg/dL)

181.7 ± 48.3

180.6 ± 45.5

0.908

Triglycerides (mg/dL)

91.3 ± 59.5

110.8 ± 68.3

0.152

HDL-C (mg/dL)

55.6 ± 12.0

54.3 ± 13.6

0.653

LDL-C (mg/dL)

111.2 ± 33.4

114.7 ± 28.3

0.598

Fasting insulin

6.7 ± 6.1

11.0 ± 15.3

0.025

2 hr insulin

38.3 ± 31.6

54.2 ± 56.7

0.087

HbA1C (%)

5.4 ± 0.3

5.5 ± 0.5

0.544

AC (mg/dL)

87.6 ± 5.8

90.4 ± 16.8

0.164

PC (mg/dL)

105.4 ± 29.9

109.3 ± 40.2

0.557

HOMA index (mg/L)

1.5 ± 1.6

2.6 ± 3.8

0.022

A/I (AC/ Fasting Insulin)

19.1 ± 11.3

17.4 ± 12.3

0.427

QUICKI index (mg/L)

3.6 ± 0.8

3.5 ± 0.8

0.454

SHBG (nmol/L)

48.5 ± 41.9

40.2 ± 42.5

0.337

17-OHP (ng/mL)

1.8 ± 1.3

2.0 ± 1.4

0.400

Hirsutism score

4.6 ± 3.3

5.8 ± 3.9

0.289

TSH (μU/mL)

2.4 ± 1.5

2.0 ± 0.9

0.044

LH (mIU/mL)

6.8 ± 4.5

7.6 ± 5.5

0.367

FSH (mIU/mL)

5.6 ± 2.3

6.0 ± 2.3

0.445

E2 (pg/mL)

42.5 ± 23.4

48.2 ± 25.5

0.217

Testosterone (ng/mL)

0.4 ± 0.3

0.5 ± 0.3

0.289

Free androgen index

4.60 ± 3.61

6.01 ± 4.61

0.217

PRL (ng/mL)

12.8 ± 6.5

12.3 ± 6.1

0.692