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Table 4 Genotypic distribution of polymorphisms in the IRS1 and IRS2 genes between the control group and the PCO group stratified by BMI

From: Association of Gly972Arg variant of insulin receptor subtrate-1 and Gly1057Asp variant of insulin receptor subtrate-2 with polycystic ovary syndrome in the Chinese population

 

Non-obese group (BMI <27)

 

Obese group (BMI≥ 27)

 
 

PCOS group

Control group

p a

PCOS group

Control group

P b

(n = 176)

(n = 83)

(n = 72)

(n = 9)

IRS-1 Gly972Arg

      

GG

156 (88.6%)

77 (92.8%)

0.792

64 (88.9%)

7 (77.8%)

0.307

GA

20 (11.4%)

6 (7.2%)

 

8 (11.1%)

2 (22.2%)

 

IRS-2 Gly1057Asp

(n = 70)

(n = 68)

 

(n = 25)

(n = 6)

 

GG

8 (11.4%)

24 (35.3%)

0.004

4 (16.0%)

1 (16.7%)

1.000

GA

15 (21.4%)

12 (17.6%)

 

3 (12.0%)

1 (16.7%)

 

AA

47 (67.1%)

32 (47.1%)

 

18 (72.0%)

4 (66.7%)

 

GG + GA

23 (32.9%)

36 (52.9%)

0.027

7 (28.0%)

2 (33.3%)

1,000

AA

47 (67.1%)

32 (47.1%)

 

18 (72.0%)

4 (66.7%)

 

IRS-1 and IRS-2

(n = 70)

(n = 68)

 

(n = 25)

(n = 6)

 

GG / GG + GA

20 (28.6%)

33 (48.5%)

0.003

6 (24.0%)

2 (3.3%)

0.834

GA / AA

43 (61.4%)

35 (51.5%)

 

15 (60.0%)

3 (50.0%)

 

GA and AA

7 (10.0%)

0 (0.0%)

 

4 (16.0%)

1 (16.7%)

 
  1. a,bComparison between the PCOS group and the control group by chi-square test.
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Journal of Ovarian Research

ISSN: 1757-2215

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