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Table 1 Clinical characteristics and IVF-ET data

From: A pilot study to search possible mechanisms of ultralong gonadotropin-releasing hormone agonist therapy in IVF-ET patients with endometriosis

 

Control group

Ultralong group

Pvalue

No. of patients

12

11

 

Age (yrs)

34.5 ± 3.4

33.5 ± 3.3

0.45

Gonadotropin dose (IU)

1502 ± 377

2209 ± 849a

0.037

Duration of COH (days)

8.6 ± 1.9

11.5 ± 3.4a

0.032

Estradiol (pg/ml)

1995 ± 1054

1280 ± 892

0.098

No. of follicles (≧15 mm)

7.1 ± 2.7

6.6 ± 3.8

0.79

No. of mature follicles (≧18 mm)

3.0 ± 2.0

3.2 ± 2.8

0.79

No. of oocytes retrieved

5.0 ± 2.9

5.7 ± 4.1

0.70

Fertilization rate (%)

51.7 (31/60)

39.7 (25/63)

0.21

Cases of IVF/ICSI

11 / 1

8 / 3

 

Cases of embryo transfer

8

8

0.79

No. of embryos transferred

1.2 ± 0.8

1.3 ± 1.0

0.74

Cases of 2–4 cell embryo/blastcyst (cryopreserved)

4 (1) / 4 (1)

6 (0) / 2 (0)

 

Implantation rate (%)

8.3 (1/12)

21.4 (3/14)

0.35

Pregnancy rate (%)

8.3 (1/12)

27.3 (3/11)

0.23

  1. Twenty-three infertile women with Stage III or IV endometriosis were recruited for this study. Eleven patients received three courses of GnRHa (1.8 mg s.c. every 28 days), followed by a standard controlled ovarian hyperstimulation (COH) for IVF-ET (ultralong group). Twelve patients received a standard COH with mid-luteal phase GnRHa down-regulation (control group). Data are shown as the mean ± SD. a; significant difference (Fisher's test or the Mann–Whitney U-test using the Bonferroni correction).