A prospective cohort study of dietary indices and incidence of epithelial ovarian cancer

Table 4 Hazard ratios (95% confidence intervals) for the association between 2-year lagged cumulative updated aMDS and ovarian cancer from 1986 through 2010 among women in the NHS

		aMDS
	N cases	≤2.6	>2.6-3.5	>3.5-4.5	>4.5-5.5	>5.5	P trend
N cases		134	119	148	136	159
Person-years		290,089	247,467	329,112	293,048	309,867
Age-adjusted	696	1.00 (Ref)	0.91 (0.71,1.17)	0.85 (0.67,1.07)	0.86 (0.68,1.10)	0.93 (0.74,1.18)	0.52
Multivariable*	696	1.00 (Ref)	0.90 (0.70,1.16)	0.83 (0.65,1.05)	0.85 (0.66,1.09)	0.91 (0.71,1.18)	0.44
Invasive*	592	1.00 (Ref)	0.93 (0.71,1.22)	0.80 (0.61,1.03)	0.86 (0.66,1.13)	0.86 (0.65,1.13)	0.25
Borderline*	57	1.00 (Ref)	0.76 (0.33,1.78)	0.93 (0.44,1.94)	0.44 (0.17,1.15)	0.81 (0.37,1.78)	0.37
Serous/poorly differentiated*	435	1.00 (Ref)	0.95 (0.69,1.31)	0.93 (0.69,1.26)	0.86 (0.63,1.18)	0.87 (0.63,1.20)	0.29
Non-serous*	148	1.00 (Ref)	0.71 (0.42,1.19)	0.52 (0.31,0.88)	0.72 (0.44,1.20)	0.85 (0.53,1.38)	0.62
Rapidly fatal*	247	1.00 (Ref)	0.78 (0.51,1.18)	0.71 (0.48,1.06)	0.83 (0.56,1.23)	0.66 (0.44,1.00)	0.11
Less aggressive*	274	1.00 (Ref)	1.25 (0.85,1.84)	0.87 (0.59,1.29)	0.88 (0.59,1.32)	1.04 (0.70,1.55)	0.59

*Adjustment factors are listed in the Statistical Analyses section.
P values for heterogeneity by subtype were 0.63, 0.89, and 0.41 for invasive versus borderline, serous/poorly differentiated versus non-serous, and rapidly fatal versus less aggressive, respectively.

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