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Table 4 Hazard ratios (95% confidence intervals) for the association between 2-year lagged cumulative updated aMDS and ovarian cancer from 1986 through 2010 among women in the NHS

From: A prospective cohort study of dietary indices and incidence of epithelial ovarian cancer

   aMDS
  N cases ≤2.6 >2.6-3.5 >3.5-4.5 >4.5-5.5 >5.5 P trend
N cases   134 119 148 136 159  
Person-years   290,089 247,467 329,112 293,048 309,867  
Age-adjusted 696 1.00 (Ref) 0.91 (0.71,1.17) 0.85 (0.67,1.07) 0.86 (0.68,1.10) 0.93 (0.74,1.18) 0.52
Multivariable* 696 1.00 (Ref) 0.90 (0.70,1.16) 0.83 (0.65,1.05) 0.85 (0.66,1.09) 0.91 (0.71,1.18) 0.44
Invasive* 592 1.00 (Ref) 0.93 (0.71,1.22) 0.80 (0.61,1.03) 0.86 (0.66,1.13) 0.86 (0.65,1.13) 0.25
Borderline* 57 1.00 (Ref) 0.76 (0.33,1.78) 0.93 (0.44,1.94) 0.44 (0.17,1.15) 0.81 (0.37,1.78) 0.37
Serous/poorly differentiated* 435 1.00 (Ref) 0.95 (0.69,1.31) 0.93 (0.69,1.26) 0.86 (0.63,1.18) 0.87 (0.63,1.20) 0.29
Non-serous* 148 1.00 (Ref) 0.71 (0.42,1.19) 0.52 (0.31,0.88) 0.72 (0.44,1.20) 0.85 (0.53,1.38) 0.62
Rapidly fatal* 247 1.00 (Ref) 0.78 (0.51,1.18) 0.71 (0.48,1.06) 0.83 (0.56,1.23) 0.66 (0.44,1.00) 0.11
Less aggressive* 274 1.00 (Ref) 1.25 (0.85,1.84) 0.87 (0.59,1.29) 0.88 (0.59,1.32) 1.04 (0.70,1.55) 0.59
  1. *Adjustment factors are listed in the Statistical Analyses section.
  2. P values for heterogeneity by subtype were 0.63, 0.89, and 0.41 for invasive versus borderline, serous/poorly differentiated versus non-serous, and rapidly fatal versus less aggressive, respectively.