Evaluating influence of the genotypes in the follicle-stimulating hormone receptor (FSHR) Ser680Asn (rs6166) polymorphism on poor and hyper-responders to ovarian stimulation: a meta-analysis

Table 1 Included articles characteristics that examined the FSHR N680S polymorphism association with ovarian response

First author	PY	[R]	Country	Ethnic group	Sample size	Type of ovarian response	Used HWE	Addressed LD	Tissue source	Genotyping	CBS
Daelemans	2004	[36]	Belgium	NHC	229	Hyper/controls	No	Yes	blood	DNA sequencing	4
Klinkert	2006	[38]	Nether-lands	NHC	105	Poor, not poor	No	Yes	blood	Taqman	5
Livshyts	2009	[39]	Ukraine	NHC	374	poor, good/controls	Yes	Yes	blood	PCR-RFLP	5
Boudjenah	2012	[1]	France	NHC	427	poor, hyper/controls	Yes	Yes	blood	Multiplex PCR	7
Binder	2012	[42]	Germany	NHC	259	low, control	No	No	blood	RT-QPCR	6
Mohiyiddeen	2013	[40]	United Kingdom	NHC	504	poor, normal, hyper	Yes	Yes	blood	Taqman	5
de Castro	2003	[37]	Spain	HC	102	poor, good	Yes	Yes	blood	RT-QPCR	5
de Castro	2004	[13]	Spain	HC	170	poor, rest of patients, high	Yes	No	blood	RT-QPCR	8
Huang	2014	[4]	China	Asian	1,250	Poor, good responders	Yes	Yes	blood	MALDI-TOF	8
Achrekar	2009	[35]	India	Asian	150	Hyper, not hyper	Yes	No	blood	RT-QPCR	5
Yan	2013	[41]	China	Asian	450	Poor, not poor, hyper, not hyper	Yes	Yes	blood	RT-QPCR	6

PY: Publication Year; [R]: Reference; NHC: Non-Hispanic Caucasian; HC: Hispanic Caucasian; HWE: Hardy-Weinberg Equilibrium; LD: Linkage Disequilibrium PCR: Polymerase Chain Reaction; RFLP: Restriction Fragment Length Polymorphism; RT-QPCR: Real-Time Quality Polymerase Chain Reaction; MALDI-TOF: Matrix Assisted Laser Desorption Ionization-Time-of-Flight; CBS: Clark-Baudouin Score: assessment of methodological quality of the included studies.

ISSN: 1757-2215