The expression of DBC1/CCAR2 is associated with poor prognosis of ovarian carcinoma

Table 3 Multivariate Cox regression analyses for overall survival and relapse-free survival in ovarian carcinomas

Characteristics	OS		RFS
Characteristics	HR (95% CI)	P	HR (95% CI)	P
Overall ovarian carcinomas^a
Age, y, ≥ 60 (vs < 60)	2.100 (1.191-3.702)	0.010
Stage, III & IV (vs I & II)	2.488 (1.295-4.780)	0.006	3.426 (1.944-6.036)	<0.001
Histologic grade, high (vs low)			3.023 (1.355-6.742)	0.007
DBC1, positive (vs negative)	2.423 (1.144-5.132)	0.021
Serous carcinomas^b
Age, y, ≥ 60 (vs < 60)	2.241 (1.212-4.144)	0.010
Stage, III & IV (vs I & II)			3.023 (1.588-5.755)	<0.001
Histologic grade, high (vs low)			4.818 (1.487-15.614)	0.009
DBC1, positive (vs negative)	3.757 (1.462-9.653)	0.006
High-grade serous carcinomas^c
Age, y, ≥ 60 (vs < 60)	1.961 (1.050-3.664)	0.035
Stage, III & IV (vs I & II)			2.488 (1.280-4.836)	0.007
DBC1, positive (vs negative)	3.828 (1.353-10.827)	0.011	2.059 (0.907-4.677)	0.084

^aThe variables included in the multivariate analysis were age, tumor stage, lymph node metastasis, presence of ascites, bilaterality of the tumor, histologic grade, BRCA1 expression, and DBC1 expression. ^bThe variables included in the multivariate analysis were age, tumor stage, histologic grade, BRCA1 expression, and DBC1 expression. ^cThe variables included in the multivariate analysis were age, tumor stage, BRCA1 expression, and DBC1 expression.

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