Figure 2

Chemotherapy and irradiation create a pro-metastatic microenvironment in various murine organs that chemoattract A2780 cells. qRT-PCR detection of A2780 human ovarian cancer cells in bone marrow (BM), liver, lung, and spleen after irradiation (1000 cGy) and chemotherapy (cisplatin). Five mice were employed per group. The results from two independent experiments are combined and shown as mean ± SD. *p < 0.05 or **p < 0.005 compared with control (organs neither irradiated nor received cisplatin).