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Figure 3 | Journal of Ovarian Research

Figure 3

From: Evidence for induction of a tumor metastasis-receptive microenvironment for ovarian cancer cells in bone marrow and other organs as an unwanted and underestimated side effect of chemotherapy/radiotherapy

Figure 3

Anti-inflammatory treatments inhibit the metastatic spread of A2780 cells. Ibuprofen (Panel a) and dexamethasone (Panel b) significantly decrease the metastatic spread of A2780 human cancer cells into bone marrow (BM), liver, lung, and spleen of SCID-Beige inbred mice. In these experiments, five mice were used per group, and the results from three independent experiments for each anti-inflammatory drug are shown as mean ± SD. *p < 0.05, **p < 0.005, or ***p < 0.0005 for the group receiving irradiation (1000 cGy) compared with the control group (no irradiation) and for the groups receiving irradiation and an anti-inflammatory drug compared with the group receiving irradiation alone.

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Journal of Ovarian Research

ISSN: 1757-2215

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