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Table 3 The diagnostic criteria of M-CSF and in combination with HE4 and CA 125 in epithelial ovarian cancer patients

From: M-CSF in a new biomarker panel with HE4 and CA 125 in the diagnostics of epithelial ovarian cancer patients

Epithelial ovarian cancer Diagnostic criteria (%) M-CSF HE4 CA 125 M-CSF+ HE4 M-CSF + CA 125 HE4+ CA 125 M-CSF + HE4 + CA 125
stage I SE 40 46 40 64 60 73 80
SP 94 94 92 90 90 88 86
PPV 87 88 87 86 86 86 85
NPV 61 63 61 71 69 76 74
stage II SE 68 29 63 80 80 81 92
SP 94 94 92 90 90 88 86
PPV 92 83 89 89 89 87 87
NPV 75 57 72 82 82 82 91
stage III SE 84 66 80 92 94 86 96
SP 94 94 92 90 90 88 86
PPV 93 92 91 90 90 86 87
NPV 85 73 82 92 94 79 94
stage IV SE 88 81 84 100 96 92 100
SP 94 94 92 90 90 88 86
PPV 93 93 91 91 91 88 88
NPV 87 84 85 100 96 92 100
Total group SE 70 55 66 84 83 84 86
SP 94 94 92 90 90 88 86
PPV 81 90 79 89 89 88 86
NPV 76 68 73 85 84 86 86
Serous epithelial SE 74 70 64 92 82 86 96
SP 94 94 92 90 90 88 86
PPV 92 92 89 90 80 79 87
NPV 78 77 73 92 83 86 96
Endometrioid epithelial SE 65 37 71 82 89 82 91
SP 94 94 92 90 90 88 86
PPV 91 86 90 89 82 87 87
NPV 73 59 81 83 89 84 92