Fig. 3

MiR-200c localized in the epithelial cancer cell and inflammatory cells but absent in stroma. a The tissue was stained with H&E to identify the cancer cellular structures. Intense LNA-miR-200c ISH signal is detected in the cytoplasmic region, predominantly in the epithelial of cancer cells. Weak miR-200c ISH signal is seen in the stromal compartment. MiR-21 (positive control) exhibits the same pattern of localization as miR-200c. The U6 ISH signal is solely in the nuclei of all cell types. There was no ISH signal detected in the negative control. Ca stands for cancer cells and St stands for stroma. b Localization of miR-200c was also detected in the inflammatory cells of SEOC. All images were captured under 200× magnifications