Risk prediction model for epithelial ovarian cancer using molecular markers and clinical characteristics

Table 2 The Cox regression analysis of prognostic factors in epithelial ovarian cancer

Factors	β	Hazard ratio	95 % confidence interval	P
Clinicopathological factors
Parity				0.009
0–1			Reference
2–3	0.103	0.668	0.410–1.089
>3	1.069	2.911	1.203–7.044
Peritoneal metastasis				0.047
No			Reference
Yes	1.086	2.963	1.013–8.664
FIGO stage				0.021
I			Reference
II	0.722	2.058	0.603–7.025
III	1.150	3.158	0.730–13.658
IV	1.470	4.351	1.611–11.746
Tumor type				<0.001
I			Reference
II	1.613	5.017	2.501–10.067
Residual disease				<0.001
≤0.5 cm			Reference
>0.5 cm	1.553	4.725	2.418–9.233
Molecular factors
HER2				<0.001
Low expression			Reference
High expression	1.242	3.463	1.839–6.523
KRAS				<0.001
Low expression			Reference
High expression	1.332	3.787	1.959–7.319
BRCA1				0.003
High expression			Reference
Low expression	0.957	2.604	1.398–4.849
BRAF				0.012
High expression			Reference
Low expression	1.043	2.838	1.261–6.383
EGFR				0.036
Low expression			Reference
High expression	0.622	1.862	1.042–3.327

ISSN: 1757-2215