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Table 4 Factors associated with post-surgical adverse DOR at 6 months after laparoscopic cystectomy

From: Evaluation of factors predicting diminished ovarian reserve before and after laparoscopic cystectomy for ovarian endometriomas: a prospective cohort study

Variables Univariate analysis Multivariate analysis
Adverse DOR (n = 38) Non-adverse DOR (n = 74) P value OR (95 % CI) P value
Patient characteristics
 Age (years) 34.6 ± 5.0 (33.0–36.3) 33.0 ± 4.8 (31.8–34.1) 0.09   
 Gravidity 0.2 ± 0.6 (0.03–0.5) 0.1 ± 0.4 (0.03–0.2) 0.30   
 Parity 0.2 ± 0.6 (0.1–0.6) 0.1 ± 0.3 (0–0.2) 0.15   
 Body mass index (kg/m2) 21.7 ± 4.5 (20.2–23.2) 21.3 ± 5.2 (20.1–22.6) 0.73   
Laterality of cysts
 Unilateral 15 (39.5) 49 (66.2) 0.007 3.71 (1.45–9.51) 0.006
 Bilateral 23 (60.5) 25 (33.8)    
 Total size of ovarian cyst (mm) 75.4 ± 32.9 (64.6–86.2) 71.9 ± 24.4 (66.2–77.5) 0.52   
Pre-surgical serum hormone concentrations
 LH (mIU/mL) 4.7 ± 4.0 (3.4–6.0) 6.9 ± 10.0 (4.6–9.2) 0.18   
 FSH (mIU/mL) 6.7 ± 2.4 (5.9–7.5) 6.4 ± 3.9 (5.4–7.3) 0.67   
 Estradiol (pg/mL) 74.1 ± 89.3 (44.8–103.4) 71.4 ± 86.7 (51.3–91.5) 0.88   
 CA125 (U/mL) 71.3 ± 48.5 (55.4–87.3) 67.6 ± 55.4 (54.8–80.4) 0.72   
 AMH (ng/mL) 2.5 ± 1.2 (2.1–2.9) 4.8 ± 3.1 (4.0–5.5) <0.001 0.43 (0.27–0.67) <0.001
Peri-surgical findings
 Re-ASRM score 61.8 ± 33.7 (50.8–72.9) 48.9 ± 26.3 (42.8–55.0) 0.03
 Total surgical duration (min) 89.8 ± 40.8 (76.4–103.2) 82.8 ± 32.3 (75.3–90.2) 0.32   
 Total blood loss (mL) 37.4 ± 45.5 (22.5–52.4) 25.4 ± 28.0 (18.9–31.8) 0.09   
  1. Abbreviations: AMH anti-Müllerian hormone, CA125 cancer antigen 125, CI confidence interval, DOR diminished ovarian reserve, FSH follicle-stimulating hormone, LH luteinising hormone, OR odds ratio, Re-ASRM revised American Society of Reproductive Medicine
  2. Data are expressed as mean ± standard deviation (95 % CI) or number (percentage) of patients