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Table 3 Performance tumour markers in predicting cytoreduction (a) or platinum sensitivity (b)

From: Serum CA125 and HE4 levels as predictors for optimal interval surgery and platinum sensitivity after neoadjuvant platinum-based chemotherapy in patients with advanced epithelial ovarian cancer

  Sensitivity Specificity PPV NPV DOR
(a)
CA125 ≤ 75 UI/ml 81.3 % 85.7 % 86.7 % 80 % 22.13
HE4 ≤ 252 pmol/l 93.3 % 50 % 70 % 85.7 % 12.57
CA125 ≤ 75 UI/ml and HE4 ≤ 252 pmol/l 93.7 % 92.3 % 93.7 % 92.3 % 96.15
(b)
CA125 ≤ 35 UI/ml 90.9 % 57.9 % 55.6 % 91.7 % 13.75
HE4 ≤ 115 pmol/l 92.9 % 68.7 % 72.2 % 91.7 % 28.6
CA125 ≤ 35 UI/ml and HE4 ≤ 115 pmol/l 92.9 % 68.7 % 72.2 % 91.7 % 28.6
  1. PPV positive predictive value, NPV negative predictive value, DOR diagnostic odd ratio