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Fig. 2 | Journal of Ovarian Research

Fig. 2

From: Dasatinib + Gefitinib, a non platinum-based combination with enhanced growth inhibitory, anti-migratory and anti-invasive potency against human ovarian cancer cells

Fig. 2

In vitro inhibition of HOAC viability by kinase inhibitors in tandem and/or in combination with carboplatin. Individual kinase inhibitors or two-kinase inhibitor combinations induce a cell-specific sensitization of HOAC to carboplatin. Combination index (CI)-fraction affected (Fa, corresponding to the fraction of cell viability inhibited) plot of HOACs treated with (a) a dose range of carboplatin (Ca) in combination with dose range of Crizotinib (Cr), Dasatinib (Da) or Gefitinib (Ge), based on a ratio of the IC50 of the two drugs, (b) kinase inhibitors in a tandem combination based on a ratio of the IC50 of the two drugs or (c) kinase inhibitors in tandem in combination with carboplatin. The dotted line represents the additivity while the synergism is considered below the line (CI < 1) and the antagonism above the line (CI > 1). d and e The combination index CI50 were determined for each drug combination

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Journal of Ovarian Research

ISSN: 1757-2215

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