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Table 6 The diagnostic criteria of the ROC curve for MMP-7, TIMP-1, HE4 and CA125 in epithelial ovarian cancer patients

From: Plasma levels of MMP-7 and TIMP-1 in laboratory diagnostics and differentiation of selected histological types of epithelial ovarian cancers

Epithelial ovarian cancer The ROC criteria MMP-7 TIMP-1 HE4 CA 125
Stage I AUC 0.7801a 0.5769 0.8343a 0.8324a
SE 0.0693 0.0718 0.0582 0.0471
95% C.I. 0.644–0.916 0.436–0.718 0.720–0.948 0.740–0.925
pAUC = 0.5 0.0001 0.2840 <0.001 <0.001
Stage II AUC 0.7938a 0.6109 0.8462a 0.8825a
SE 0.0639 0.0772 0.0479 0.0397
95% C.I. 0.669–0.919 0.460–0.762 0.752–0.940 0.805–0.960
pAUC = 0.5 <0.001 0.1506 <0.001 <0.001
Stage III AUC 0.8905a 0.7740a 0.9521a 0.9331a
SE 0.0485 0.0643 0.0288 0.0327
95% C.I. 0.796–0.986 0.648–0.900 0.896–1.008 0.869–0.997
pAUC = 0.5 <0.001 <0.001 <0.001 <0.001
Stage IV AUC 0.8679a 0.7314a 0.8994a 0.9458a
SE 0.0624 0.0778 0.0511 0.0252
95% C.I. 0.746–0.990 0.579–0.884 0.799–1.000 0.896–0.995
pAUC = 0.5 <0.001 0.0029 <0.001 <0.001
Total group AUC 0.8335a 0.6372a 0.8836a 0.8988a
SE 0.330 0.0425 0.0263 0.0235
95% C.I. 0.769–0.898 0.554–0.721 0.832–0.935 0.853–0.945
pAUC = 0.5 <0.001 0.0013 <0.001 <0.001
  1. C.I. – confidence intervals of AUC
  2. aStatistically significant when comparing tested parameters AUC’s with 0.5 AUC
  3. Bold data are statistically significant when p < 0.05