Table 4 Point estimates and 95% confidence interval of CA-125 at various cut off points
Cut off | True prevalence | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | +LR Ratio | -LR Ratio | Odds Ratio | Youden index | Accuracy(%) |
|---|---|---|---|---|---|---|---|---|---|---|
≥35 | 54.8 | 87 | 19.3 | 56.6 | 55 | 1.078 | 0.676 | 1.594 | 0.063 | 56.35 |
≥50 | 54.8 | 84.1 | 42.1 | 63.7 | 68.6 | 1.452 | 0.379 | 3.835 | 0.262 | 65.08 |
≥100 | 54.8 | 72.5 | 78.9 | 80.6 | 70.3 | 3.442 | 0.349 | 9.868 | 0.514 | 76.19 |
≥143 | 54.8 | 62.319 | 96.491 | 93.5 | 67.5 | 11.841 | 0.398 | 29.769 | 0.571 | 77.78 |