Skip to main content
Fig. 1 | Journal of Ovarian Research

Fig. 1

From: Sialylation of EGFR by the ST6Gal-I sialyltransferase promotes EGFR activation and resistance to gefitinib-mediated cell death

Fig. 1

ST6Gal-I promotes an increase in overall tyrosine kinase activity. a. OV4 cells were stably transduced with lentivirus encoding ST6Gal-I, and ST6Gal-I overexpression (OE) was confirmed by immunoblotting (EV = empty vector control). b. Whole array image capture at final prewash cycle number 92 of PTK array illustrating changes in tyrosine phosphorylation with qualitatively selected altered spots (yellow arrows) increased in ST6Gal-I OV4 OE cells as compared to EV cells. c. Whole chip comparative OE and EV array-mean phosphorylation intensity (y axis per cell) over time in the kinetic/prewash cycles (x axis per cell) for both the STK (left 2 panels) and PTK (right two panels) arrays. d. EV or OE cells were immunoblotted with an anti-phosphotyrosine antibody

Back to article page

Journal of Ovarian Research

ISSN: 1757-2215

Contact us