Differential cyclooxygenase expression levels and survival associations in type I and type II ovarian tumors

Beeghly-Fadiel, Alicia; Wilson, Andrew J.; Keene, Spencer; El Ramahi, Meral; Xu, Shu; Marnett, Lawrence J.; Fadare, Oluwole; Crispens, Marta A.; Khabele, Dineo

doi:10.1186/s13048-018-0389-9

Journal of Ovarian Research

Table 2 Associations between COX expression levels and clinical covariates, the Vanderbilt TROC

From: Differential cyclooxygenase expression levels and survival associations in type I and type II ovarian tumors

	COX-1 / PTGS-1					COX-2 / PTGS-2
	Standard IHC scoring			H-Score		Standard IHC scoring			H-Score
Characteristic	N (%) weak	Moderate & strong	P-value	Mean (std err)	P-value	N (%) weak	Moderate & strong	P-value	Mean (std err)	P-value
Age
< 57.6	39 (50.7)	56 (49.6)	0.883	91.2 (9.4)	0.889	46 (44.7)	49 (56.3)	0.109	77.6 (8.8)	0.047
≥ 57.6	38 (49.4)	57 (50.4)	0.883	93.0 (9.3)	0.889	57 (55.3)	38 (43.7)	0.109	54.6 (7.3)	0.047
Stage
I/II	32 (41.6)	25 (22.1)	0.004	72.1 (11.9)	0.047	17 (16.5)	40 (46.0)	< 0.001	111.5 (12.8)	< 0.001
III/IV/Unstaged	45 (58.4)	88 (77.9)	0.004	100.6 (7.9)	0.047	86 (83.5)	47 (54.0)	< 0.001	46.7 (5.4)	< 0.001
Histologic Subtype
Serous	47 (61.0)	12 (10.6)	< 0.001	116.5 (7.6)	< 0.001	82 (79.6)	49 (56.3)	< 0.001	49.7 (5.4)	< 0.001
Non-Serous	30 (39.0)	101 (89.4)	< 0.001	37.9 (9.7)	< 0.001	21 (20.4)	38 (43.7)	< 0.001	102.7 (13.2)	< 0.001
Grade
Low Grade	15 (19.5)	18 (15.9)	0.526	92.4 (16.4)	0.982	5 (4.9)	28 (32.2)	< 0.001	134.0 (16.1)	< 0.001
High Grade	62 (80.5)	95 (84.1)	0.526	92.0 (7.2)	0.982	98 (95.2)	59 (67.8)	< 0.001	51.9 (5.5)	< 0.001
Type
Type I Tumors	39 (50.7)	26 (23.0)	< 0.001	68.4 (11.1)	0.009	19 (18.5)	46 (52.9)	< 0.001	113.4 (12.2)	< 0.001
Type II Tumors	38 (49.4)	87 (77.0)	< 0.001	104.4 (8.0)	0.009	84 (81.6)	41 (47.1)	< 0.001	41.5 (4.8)	< 0.001
Residual Disease^a
Optimal	22 (43.1)	25 (29.4)	0.103	78.4 (12.2)	0.177	16 (21.1)	31 (51.7)	< 0.001	109.1 (14.0)	< 0.001
Suboptimal	29 (56.9)	60 (70.6)	0.103	97.3 (9.3)	0.177	60 (79.0)	29 (48.3)	< 0.001	42.4 (6.1)	< 0.001
Platinum Sensitivity^b
Resistant	12 (30.0)	27 (33.8)	0.679	93.0 (13.6)	0.884	28 (40.0)	11 (22.0)	0.038	37.7 (8.7)	0.030
Sensitive	28 (70.0)	53 (66.3)	0.679	95.5 (9.7)	0.884	42 (60.0)	39 (78.0)	0.038	63.8 (8.2)	0.030

Bold values denote signficant associations; column percentages may not sum to 100% due to rounding error
^aAmong cases with known cytoreductive status
^bAmong cases treated with platinum with response to treatment known

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