Assessment of Prostaglandin-Endoperoxide Synthase 2 and Versican gene expression profile from the cumulus cells: association with better in vitro fertilization outcomes

Ocampo, Azucena; Pedraza, Jeimy; Ortiz, Ginna; Hernández-Pérez, Elizabeth; Porchia, Leonardo; López-Bayghen, Esther

doi:10.1186/s13048-018-0456-2

Table 2 The association between the probability and pregnancy determined by β–hCG or USG

From: Assessment of Prostaglandin-Endoperoxide Synthase 2 and Versican gene expression profile from the cumulus cells: association with better in vitro fertilization outcomes

Category	Size	OR ^a	95% CI	p-value
Pregnancy by β–hCG
Probability raw score^b
Overall	149	11.59	4.27–31.84	< 0.001 *
Patient’s age
< 38 years of age	63	11.46	2.16–60.65	0.004 *
≥ 38 years of age	86	12.41	3.48–44.21	< 0.001 *
Pre-implantation Genetic Testing (PGT)
No PGT confirmed euploid embryo	104	6.81	2.03–22.86	0.002 *
PGT confirmed euploid embryo	45	51.23	6.46–406.25	< 0.001 *
Patient’s health
No major etiology	131	17.43	5.48–55.44	< 0.001 *
Presence of a major etiology	18	4.48	0.19–104.06	0.350
At least 1 PVL positive embryo ^c
Overall	149	17.15	6.82–43.18	< 0.001 *
Patient’s age
< 38 years of age	63	13.60	3.71–49.91	< 0.001 *
≥ 38 years of age	86	21.93	5.73–83.94	< 0.001 *
Pre-implantation Genetic Testing (PGT)
No PGT confirmed euploid embryo	104	9.67	3.54–26.43	< 0.001 *
PGT confirmed euploid embryo	45	N/D
Patient’s health
No major etiology	131	29.17	10.43–81.56	< 0.001 *
Presence of a major etiology	18	1.20	0.09–15.26	0.888
Pregnancy by Ultrasound confirmation
Probability raw score ^b
Overall	149	8.40	3.26–21.63	< 0.001 *
Patient’s age
< 38 years of age	63	3.84	0.92–16.12	0.066
≥ 38 years of age	86	14.79	4.08–53.61	< 0.001 *
Pre-implantation Genetic Testing (PGT)
No PGT confirmed euploid embryo	104	6.31	1.94–20.50	0.002 *
PGT confirmed euploid embryo	45	21.62	3.53–132.42	0.001 *
Patient’s health
No major etiology	131	10.75	3.77–30.65	< 0.001 *
Presence of a major etiology	18	4.48	0.19–104.06	0.350
At least 1 PVL positive embryo ^c
Overall	149	16.81	6.43–43.92	< 0.001 *
Patient’s age
< 38 years of age	63	9.48	2.66–33.78	0.001 *
≥ 38 years of age	86	31.63	6.68–149.79	< 0.001 *
Pre-implantation Genetic Testing (PGT)
No PGT confirmed euploid embryo	104	10.27	3.64–28.96	< 0.001 *
PGT confirmed euploid embryo	45	N/D
Patient’s health
No major etiology	131	26.91	9.29–77.94	< 0.001 *
Presence of a major etiology	18	1.20	0.09–15.26	0.888

^aCrude odds ratio (OR) and 95% confidence intervals (95% CI) were determined using logistic regression. N/D = was not able to be determined. *indicates a significant result, p < 0.05 (two-tailed). ^bProbability = 1-(x_neg/x_tot)ⁿ, where x_neg = number of embryos with a PVL index score < 58.2, x_tot = total number of transferred embryos, and n = number of embryos with a PVL index score ≥ 58.2. ^cA positive cohort has the probability ≠0.00

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