Table 3 KEGG enrichment analysis of differentially expressed genes
From: Identification of core genes in ovarian cancer by an integrative meta-analysis
Term | C | O | E | R | P Value | Genes |
|---|---|---|---|---|---|---|
Up-regulated | ||||||
hsa04110: Cell cycle | 124 | 11 | 1.90 | 5.79 | 2.64E-06 | E2F3, SFN, MCM4, BUB1, BUB1B, TTK, YWHAZ, CCNE1, CCNB2, CDK1, CDC20 |
hsa04530: Tight junction | 139 | 9 | 2.13 | 4.22 | 0.00026240 | CLDN4, CLDN3, CLDN7, TJP3, KRAS, LLGL2, PRKCI, CLDN10, MAGI1 |
hsa04114: Oocyte meiosis | 124 | 8 | 1.90 | 4.21 | 0.00059620 | ITPR3, BUB1, YWHAZ, CCNE1, CCNB2, CALML4, CDK1, CDC20 |
hsa01230: Biosynthesis of amino acids | 75 | 6 | 1.15 | 5.22 | 0.00096638 | PSAT1, IDH2, PFKP, PKM, PYCR1, TPI1 |
hsa00051: Fructose and mannose metabolism | 33 | 4 | 0.51 | 7.91 | 0.00151933 | PFKP, SORD, TPI1, TSTA3 |
Down-regulated | ||||||
hsa04610: Complement and coagulation cascades | 79 | 7 | 1.42 | 4.93 | 0.00051053 | PROCR, CFH, TFPI, THBD, C1S, C4BPB, C7 |
hsa04022: cGMP-PKG signaling pathway | 168 | 10 | 3.02 | 3.31 | 0.00084616 | AKT3, ADCY2, EDNRA, AKT2, GATA4, ITPR1, KCNJ8, MEF2C, PLN, RGS2 |
hsa04726: Serotonergic synapse | 113 | 8 | 2.03 | 3.94 | 0.00092536 | DUSP1, GNG4, GNG11, HTR2B, ITPR1, MAOA, MAOB, TRPC1 |
hsa04550: Signaling pathways regulating pluripotency of stem cells | 142 | 9 | 2.55 | 3.53 | 0.00098921 | AKT3, AKT2, APC, ID3, IL6ST, WNT4, TBX3, LEFTY2, KLF4 |
hsa04270: Vascular smooth muscle contraction | 121 | 8 | 2.18 | 3.68 | 0.00144356 | CALCRL, ADCY2, EDNRA, ITPR1, PPP1R12B, PLA2G1B, PLA2G5, CALD1 |