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Table 4 Five top genes mutated at least twice with an absolute fold-change ≥ 2 and p ≤ 0.01 of RNA expression between tumor and normal tissue samples

From: Next-generation sequencing-based genomic profiling analysis reveals novel mutations for clinical diagnosis in Chinese primary epithelial ovarian cancer patients

Gene information DNA mutant RNA-Seq
Gene NAME CHR Count Fold-change p-value
TTN Titin 2 4 −2.48 0.0054772
MUC16 Mucin 16, cell surface associated 19 3 8.05 0.00013
BRCA1 Breast cancer1, early onset 17 2 2.37 0.0011747
NRAS Neurablastoma RAS viral oncogene homolog 1 2 2.21 0.000907
INSR Insulin receptor 1 2 −2.08 0.0011705