Next-generation sequencing-based genomic profiling analysis reveals novel mutations for clinical diagnosis in Chinese primary epithelial ovarian cancer patients

Table 4 Five top genes mutated at least twice with an absolute fold-change ≥ 2 and p ≤ 0.01 of RNA expression between tumor and normal tissue samples

Gene information			DNA mutant	RNA-Seq
Gene	NAME	CHR	Count	Fold-change	p-value
TTN	Titin	2	4	−2.48	0.0054772
MUC16	Mucin 16, cell surface associated	19	3	8.05	0.00013
BRCA1	Breast cancer1, early onset	17	2	2.37	0.0011747
NRAS	Neurablastoma RAS viral oncogene homolog	1	2	2.21	0.000907
INSR	Insulin receptor	1	2	−2.08	0.0011705

ISSN: 1757-2215