Table 2 Gene ontology analysis of differentially expressed genes in ovarian cancer

Up-regulated

GOTERM_BP_DIRECT

GO:0051301~cell division

16

15.24

9.45E-10

1.43E-06

GOTERM_BP_DIRECT

GO:0007067~mitotic nuclear division

14

13.33

1.21E-09

1.84E-06

GOTERM_BP_DIRECT

GO:0007062~sister chromatid cohesion

8

7.62

1.76E-06

0.002667

GOTERM_BP_DIRECT

GO:0051726~regulation of cell cycle

8

7.62

6.07E-06

0.009214

GOTERM_BP_DIRECT

GO:0034501~protein localization to kinetochore

4

3.81

1.98E-05

0.030061

GOTERM_BP_DIRECT

GO:0008283~cell proliferation

11

10.48

3.81E-05

0.057753

GOTERM_CC_DIRECT

GO:0005654~nucleoplasm

37

35.24

8.26E-08

9.94E-05

GOTERM_CC_DIRECT

GO:0030496~midbody

9

8.57

3.99E-07

4.80E-04

GOTERM_CC_DIRECT

GO:0005876~spindle microtubule

6

5.71

3.37E-06

0.004057

GOTERM_CC_DIRECT

GO:0005819~spindle

8

7.62

3.49E-06

0.004203

GOTERM_CC_DIRECT

GO:0005829~cytosol

35

33.33

4.42E-05

0.053183

GOTERM_CC_DIRECT

GO:0005634~nucleus

48

45.71

5.52E-05

0.066432

GOTERM_MF_DIRECT

GO:0005515~protein binding

72

68.57

5.60E-07

7.08E-04

GOTERM_MF_DIRECT

GO:0043565~sequence-specific DNA binding

11

10.48

5.14E-04

0.647343

GOTERM_MF_DIRECT

GO:0008017~microtubule binding

7

6.67

9.63E-04

1.210835

GOTERM_MF_DIRECT

GO:0008574~ATP-dependent microt-ubule motor activity, plus-end-directed

3

2.86

0.003788

4.685832

GOTERM_MF_DIRECT

GO:0019901~protein kinase binding

8

7.62

0.0044544

5.488301

Down-regulated

GOTERM_BP_DIRECT

GO:0060021~palate development

5

4.91

4.95E-04

0.721802

GOTERM_BP_DIRECT

GO:0007596~blood coagulation

6

5.89

0.001956

2.823695

GOTERM_BP_DIRECT

GO:0045944~positive regulation of transcription from RNA polymerase II promoter

12

11.76

0.00728

10.1353

GOTERM_BP_DIRECT

GO:0000122~negative regulation of transcription from RNA polymerase II promoter

10

9.80

0.00773

10.72979

GOTERM_BP_DIRECT

GO:0007409~axonogenesis

4

3.92

0.011841

15.98884

GOTERM_BP_DIRECT

GO:0031623~receptor internalization

3

2.94

0.018262

23.62882

GOTERM_CC_DIRECT

GO:0031225~anchored component of membrane

5

4.90

0.002893

3.225113

GOTERM_CC_DIRECT

GO:0005576~extracellular region

17

16.67

0.008777

9.4952

GOTERM_CC_DIRECT

GO:0005578~proteinaceous extracellular matrix

6

5.88

0.013131

13.89424

GOTERM_CC_DIRECT

GO:0005615~extracellular space

14

13.72

0.022365

22.58432

GOTERM_MF_DIRECT

GO:0043565~sequence-specific DNA binding

10

9.80

0.00117

1.454993

GOTERM_MF_DIRECT

GO:0001078~transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding

4

3.92

0.018506

20.85873

GOTERM_MF_DIRECT

GO:0001085~RNA polymerase II transcription factor binding

3

2.94

0.023394

25.65558

GOTERM_MF_DIRECT

GO:0001077~transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding

5

4.90

0.031296

32.84726

GOTERM_MF_DIRECT

GO:0008083~growth factor activity

4

3.92

0.048426

46.29421