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Table 2 Gene ontology analysis of differentially expressed genes in ovarian cancer

From: Identification of significant genes with poor prognosis in ovarian cancer via bioinformatical analysis

Expression Category Term Count % p-Value FDR
Up-regulated GOTERM_BP_DIRECT GO:0051301~cell division 16 15.24 9.45E-10 1.43E-06
GOTERM_BP_DIRECT GO:0007067~mitotic nuclear division 14 13.33 1.21E-09 1.84E-06
GOTERM_BP_DIRECT GO:0007062~sister chromatid cohesion 8 7.62 1.76E-06 0.002667
GOTERM_BP_DIRECT GO:0051726~regulation of cell cycle 8 7.62 6.07E-06 0.009214
GOTERM_BP_DIRECT GO:0034501~protein localization to kinetochore 4 3.81 1.98E-05 0.030061
GOTERM_BP_DIRECT GO:0008283~cell proliferation 11 10.48 3.81E-05 0.057753
GOTERM_CC_DIRECT GO:0005654~nucleoplasm 37 35.24 8.26E-08 9.94E-05
GOTERM_CC_DIRECT GO:0030496~midbody 9 8.57 3.99E-07 4.80E-04
GOTERM_CC_DIRECT GO:0005876~spindle microtubule 6 5.71 3.37E-06 0.004057
GOTERM_CC_DIRECT GO:0005819~spindle 8 7.62 3.49E-06 0.004203
GOTERM_CC_DIRECT GO:0005829~cytosol 35 33.33 4.42E-05 0.053183
GOTERM_CC_DIRECT GO:0005634~nucleus 48 45.71 5.52E-05 0.066432
GOTERM_MF_DIRECT GO:0005515~protein binding 72 68.57 5.60E-07 7.08E-04
GOTERM_MF_DIRECT GO:0043565~sequence-specific DNA binding 11 10.48 5.14E-04 0.647343
GOTERM_MF_DIRECT GO:0008017~microtubule binding 7 6.67 9.63E-04 1.210835
GOTERM_MF_DIRECT GO:0008574~ATP-dependent microt-ubule motor activity, plus-end-directed 3 2.86 0.003788 4.685832
GOTERM_MF_DIRECT GO:0019901~protein kinase binding 8 7.62 0.0044544 5.488301
Down-regulated GOTERM_BP_DIRECT GO:0060021~palate development 5 4.91 4.95E-04 0.721802
GOTERM_BP_DIRECT GO:0007596~blood coagulation 6 5.89 0.001956 2.823695
GOTERM_BP_DIRECT GO:0045944~positive regulation of transcription from RNA polymerase II promoter 12 11.76 0.00728 10.1353
GOTERM_BP_DIRECT GO:0000122~negative regulation of transcription from RNA polymerase II promoter 10 9.80 0.00773 10.72979
GOTERM_BP_DIRECT GO:0007409~axonogenesis 4 3.92 0.011841 15.98884
GOTERM_BP_DIRECT GO:0031623~receptor internalization 3 2.94 0.018262 23.62882
GOTERM_CC_DIRECT GO:0031225~anchored component of membrane 5 4.90 0.002893 3.225113
GOTERM_CC_DIRECT GO:0005576~extracellular region 17 16.67 0.008777 9.4952
GOTERM_CC_DIRECT GO:0005578~proteinaceous extracellular matrix 6 5.88 0.013131 13.89424
GOTERM_CC_DIRECT GO:0005615~extracellular space 14 13.72 0.022365 22.58432
GOTERM_MF_DIRECT GO:0043565~sequence-specific DNA binding 10 9.80 0.00117 1.454993
GOTERM_MF_DIRECT GO:0001078~transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding 4 3.92 0.018506 20.85873
GOTERM_MF_DIRECT GO:0001085~RNA polymerase II transcription factor binding 3 2.94 0.023394 25.65558
GOTERM_MF_DIRECT GO:0001077~transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding 5 4.90 0.031296 32.84726
GOTERM_MF_DIRECT GO:0008083~growth factor activity 4 3.92 0.048426 46.29421