Fig. 3

RLIP76 potential function in ovarian corpus luteum. The tumor and corpus luteum share similar physiological events in obtaining an adequate supply of nutrient by gaining access to the host vascular system. In tumor development, RLIP76 actively participates in regulating the cell migration and spreading required for angiogenesis. Furthermore, RLIP76 plays an essential role in tumor angiogenesis through the regulation of pro-angiogenic factors such as VEGF and HIF-1. In addition, those pro-angiogenic factors were discovered to be upregulated during the corpus luteum angiogenesis. Taken together, the RLIP76 may be required for corpus luteum formation and its physiological function. However, further investigation is necessary to discover and elucidate the potential function of RLIP76 in ovarian corpus luteum regulation