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Table 2 Factors associated with overall survival

From: Effect of BRCA mutational status on survival outcome in advanced-stage high-grade serous ovarian cancer

Characteristics

N

Univariate analysis

Multivariate analysis

HR

95% CI

P

Adjusted HR

95% CI

P

Age, years

 <50

39

1 (Ref)

−

−

1 (Ref)

−

−

 ≥50

89

2.848

0.825−9.835

0.098

2.407

0.668−8.670

0.179

FIGO stage

 III

77

1 (Ref)

−

−

1 (Ref)

−

−

 IV

51

2.055

0.734−5.753

0.170

1.248

0.434−3.591

0.682

Primary treatment strategy

 PDS

79

1 (Ref)

−

−

1 (Ref)

−

−

 NAC

49

3.790

1.483−9.691

0.005

4.098

1.478−11.359

0.007

Residual tumor after PDS/IDS

 Optimal debulking

109

1 (Ref)

−

−

1 (Ref)

−

−

 Suboptimal debulking

19

1.723

0.545−5.442

0.354

1.935

0.559−6.703

0.298

BRCA status

 Wild-type

77

1 (Ref)

−

−

1 (Ref)

−

−

 Mutation

51

0.584

0.228−1.495

0.262

0.768

0.283−2.082

0.603

  1. Abbreviations: CA-125 cancer antigen 125, FIGO International Federation of Gynecology and Obstetrics, PDS primary debulking surgery, NAC neoadjuvant chemotherapy, IDS interval debulking surgery, HR hazard ratio, CI confidence interval, Ref reference