0.05); TFSR was 100% in OBC, NS and TS. No significant differences in TRR (p > 0.05); AF were found only in OBC; TFSR was 100% after transplantation; significantly higher FGR in the 2.5 months compared to the 1.5 months-group (p  < 0.05). AMH- and E2-level in group 1 and 3 were significantly higher than in group 2 (p < 0.05); in contrast, FSH was significantly lower. Conclusions After transplantation in the mice, the thawed ovarian tissue survived and follicles developed. The ovarian fossa site was the best site for transplantation. Our animal experiments can verify that our human ovarian tissue cryopreservation technique can preserve the quality of ovarian tissue. This is the essential precondition for successful re-transplantation into the patients after performing chemo/radiotherapy to protect ovarian function and fertility."/>
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Table 4 FSH, AMH, E2 values comparison across three groups (\( \overline{x}\pm s \))

From: Randomized study to prove the quality of human ovarian tissue cryopreservation by xenotransplantation into mice

Comparison Group FSH(mIU/ml) AMH(pg/ml) E2(pg/ml)
Transplantation group 5.41 ± 1.73 342.71 ± 166.82 243.45 ± 234.47
Control group 9.12 ± 3.56 294.79 ± 152.42 254.69 ± 373.86
Ovariectomized group 5.41 ± 1.73 203.24 ± 32.47 64.54 ± 295.48
F 9.23 4.29 2.05
p-value 0.00 0.02 0.04
  1. Note: After ANOVA test, the post-hoc analysis showed that there were statistical difference for FSH(Ovariectomized group VS Control group, Transplantation group VS Ovariectomized group, with p-value of 0.00 and 0.00, respectively), for AMH(Ovariectomized group VS Control group, Transplantation group VS Ovariectomized group, with p-value of 0.02 and 0.00, respectively),for E2(Ovariectomized group VS Control group, Transplantation group VS Ovariectomized group, with p-value of 0.04 and 0.04, respectively), whereas there were no statistical difference for FSH(Transplantation group VS Control group,with p-value of 0.86), for AMH(Transplantation group VS Control group,with p-value of 0.30),for E2(Transplantation group VS Control group,with p-value of 0.55).FSH: follicle stimulating hormone(mIU/ml);AMH:Anti-Mullerian hormone(pg/ml);E2:estradiol(pg/ml)