Table 2 Hub proteins with significant centrality values, based on degree
Num | Hub genes | Protein name | Degree |
|---|---|---|---|
1 | ACTB | actin beta(ACTB) | 913 |
2 | APOA1 | apolipoprotein A1(APOA1) | 261 |
3 | PRDX2 | peroxiredoxin 2(PRDX2) | 148 |
4 | TAGLN | transgelin(TAGLN) | 70 |
5 | HP | haptoglobin(HP) | 58 |
6 | KRT1 | keratin 1(KRT1) | 31 |
7 | ACTG1 | actin gamma 1(ACTG1) | 21 |
8 | ERBB2 | erb-b2 receptor tyrosine kinase 2(ERBB2) | 16 |
9 | CFL2 | cofilin 2(CFL2) | 14 |
10 | CFL1 | cofilin 1(CFL1) | 13 |
11 | LCAT | lecithin-cholesterol acyltransferase(LCAT) | 12 |
12 | APP | amyloid beta precursor protein(APP) | 11 |
13 | ESR1 | estrogen receptor 1(ESR1) | 11 |
14 | APOE | apolipoprotein E(APOE) | 11 |
15 | DSTN | destrin, actin depolymerizing factor(DSTN) | 11 |
16 | NCF1 | neutrophil cytosolic factor 1(NCF1) | 10 |
17 | VCAM1 | vascular cell adhesion molecule 1(VCAM1) | 10 |
18 | FBXO25 | F-box protein 25(FBXO25) | 10 |
19 | SMAD3 | SMAD family member 3(SMAD3) | 9 |
20 | ABCA1 | ATP binding cassette subfamily A member 1(ABCA1) | 9 |
21 | SMARCA4 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4(SMARCA4) | 9 |
22 | TINF2 | TERF1 interacting nuclear factor 2(TINF2) | 8 |
23 | FN1 | fibronectin 1(FN1) | 7 |
24 | YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta(YWHAZ) | 7 |
25 | NOS3 | nitric oxide synthase 3(NOS3) | 7 |
26 | TTR | transthyretin(TTR) | 6 |
27 | JUN | Jun proto-oncogene, AP-1 transcription factor subunit(JUN) | 6 |
28 | IQGAP1 | IQ motif containing GTPase activating protein 1(IQGAP1) | 6 |
29 | PFN1 | profilin 1(PFN1) | 6 |
30 | HNRNPU | heterogeneous nuclear ribonucleoprotein U(HNRNPU) | 6 |
31 | POLR2A | RNA polymerase II subunit A(POLR2A) | 6 |
32 | PPARG | peroxisome proliferator activated receptor gamma(PPARG) | 5 |
33 | SCARB1 | scavenger receptor class B member 1(SCARB1) | 5 |
34 | CMTM5 | CKLF like MARVEL transmembrane domain containing 5(CMTM5) | 5 |
35 | HSPA8 | heat shock protein family A (Hsp70) member 8(HSPA8) | 5 |
36 | NSMAF | neutral sphingomyelinase activation associated factor(NSMAF) | 5 |
37 | TRAF3IP1 | TRAF3 interacting protein 1(TRAF3IP1) | 5 |
38 | SS18 | SS18, nBAF chromatin remodeling complex subunit(SS18) | 5 |
39 | SYT-SSX1 | Synovial sarcoma typically | 5 |
40 | CAP2 | CAP, adenylate cyclase-associated protein, 2 (yeast)(CAP2) | 5 |
41 | MYH9 | myosin heavy chain 9(MYH9) | 5 |
42 | EMD | emerin(EMD) | 5 |
43 | FBLN1 | fibulin 1(FBLN1) | 4 |
44 | KRT9 | keratin 9(KRT9) | 4 |
45 | ACD | adrenocortical dysplasia homolog(ACD) | 4 |
46 | POT1 | protection of telomeres 1(POT1) | 4 |
47 | RAD52 | RAD52 homolog, DNA repair protein(RAD52) | 4 |
48 | CDC37 | cell division cycle 37(CDC37) | 4 |
49 | NFKB1 | nuclear factor kappa B subunit 1(NFKB1) | 4 |
50 | OTUB1 | OTU deubiquitinase, ubiquitin aldehyde binding 1(OTUB1) | 4 |
51 | UTY | ubiquitously transcribed tetratricopeptide repeat containing, Y-linked(UTY) | 4 |
52 | GRB2 | growth factor receptor bound protein 2(GRB2) | 4 |
53 | MIS12 | MIS12, kinetochore complex component(MIS12) | 4 |
54 | TXN | thioredoxin(TXN) | 4 |
55 | APOC1 | apolipoprotein C1(APOC1) | 4 |
56 | FGA | fibrinogen alpha chain(FGA) | 4 |
57 | KRT16 | keratin 16(KRT16) | 4 |
58 | APOB | apolipoprotein B(APOB) | 4 |
59 | NAXE | NAD(P)HX epimerase(NAXE) | 4 |