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Table 2 Hub proteins with significant centrality values, based on degree

From: Proteome profiling of low grade serous ovarian cancer

Num Hub genes Protein name Degree
1 ACTB actin beta(ACTB) 913
2 APOA1 apolipoprotein A1(APOA1) 261
3 PRDX2 peroxiredoxin 2(PRDX2) 148
4 TAGLN transgelin(TAGLN) 70
5 HP haptoglobin(HP) 58
6 KRT1 keratin 1(KRT1) 31
7 ACTG1 actin gamma 1(ACTG1) 21
8 ERBB2 erb-b2 receptor tyrosine kinase 2(ERBB2) 16
9 CFL2 cofilin 2(CFL2) 14
10 CFL1 cofilin 1(CFL1) 13
11 LCAT lecithin-cholesterol acyltransferase(LCAT) 12
12 APP amyloid beta precursor protein(APP) 11
13 ESR1 estrogen receptor 1(ESR1) 11
14 APOE apolipoprotein E(APOE) 11
15 DSTN destrin, actin depolymerizing factor(DSTN) 11
16 NCF1 neutrophil cytosolic factor 1(NCF1) 10
17 VCAM1 vascular cell adhesion molecule 1(VCAM1) 10
18 FBXO25 F-box protein 25(FBXO25) 10
19 SMAD3 SMAD family member 3(SMAD3) 9
20 ABCA1 ATP binding cassette subfamily A member 1(ABCA1) 9
21 SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4(SMARCA4) 9
22 TINF2 TERF1 interacting nuclear factor 2(TINF2) 8
23 FN1 fibronectin 1(FN1) 7
24 YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta(YWHAZ) 7
25 NOS3 nitric oxide synthase 3(NOS3) 7
26 TTR transthyretin(TTR) 6
27 JUN Jun proto-oncogene, AP-1 transcription factor subunit(JUN) 6
28 IQGAP1 IQ motif containing GTPase activating protein 1(IQGAP1) 6
29 PFN1 profilin 1(PFN1) 6
30 HNRNPU heterogeneous nuclear ribonucleoprotein U(HNRNPU) 6
31 POLR2A RNA polymerase II subunit A(POLR2A) 6
32 PPARG peroxisome proliferator activated receptor gamma(PPARG) 5
33 SCARB1 scavenger receptor class B member 1(SCARB1) 5
34 CMTM5 CKLF like MARVEL transmembrane domain containing 5(CMTM5) 5
35 HSPA8 heat shock protein family A (Hsp70) member 8(HSPA8) 5
36 NSMAF neutral sphingomyelinase activation associated factor(NSMAF) 5
37 TRAF3IP1 TRAF3 interacting protein 1(TRAF3IP1) 5
38 SS18 SS18, nBAF chromatin remodeling complex subunit(SS18) 5
39 SYT-SSX1 Synovial sarcoma typically 5
40 CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)(CAP2) 5
41 MYH9 myosin heavy chain 9(MYH9) 5
42 EMD emerin(EMD) 5
43 FBLN1 fibulin 1(FBLN1) 4
44 KRT9 keratin 9(KRT9) 4
45 ACD adrenocortical dysplasia homolog(ACD) 4
46 POT1 protection of telomeres 1(POT1) 4
47 RAD52 RAD52 homolog, DNA repair protein(RAD52) 4
48 CDC37 cell division cycle 37(CDC37) 4
49 NFKB1 nuclear factor kappa B subunit 1(NFKB1) 4
50 OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1(OTUB1) 4
51 UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked(UTY) 4
52 GRB2 growth factor receptor bound protein 2(GRB2) 4
53 MIS12 MIS12, kinetochore complex component(MIS12) 4
54 TXN thioredoxin(TXN) 4
55 APOC1 apolipoprotein C1(APOC1) 4
56 FGA fibrinogen alpha chain(FGA) 4
57 KRT16 keratin 16(KRT16) 4
58 APOB apolipoprotein B(APOB) 4
59 NAXE NAD(P)HX epimerase(NAXE) 4