Combined score of pretreatment platelet count and CA125 level (PLT-CA125) stratified prognosis in patients with FIGO stage IV epithelial ovarian cancer

Table 2 Univariate and multivariate Cox models for OS and PFS

Variables	OS						PFS
	Univariate			Multivariate			Univariate			Multivariate
	HR	95% CI	p	HR	95% CI	p	HR	95% CI	p	HR	95% CI	p
Age (yr)
< 55	Reference						Reference
≧55	1.154	0.686–1.939	0.589				0.933	0.608–1.431	0.751
Histology, n (%)
HGSC	Reference			Reference			Reference
Non-HGSC	1.840	1.053–3.216	0.032	2.121	1.196–3.764	0.010	1.356	0.813–2.264	0.244
Primary treatment, n (%)
PDS + chemotherapy	Reference						Reference			Reference
NACT+IDS/ Chemotherapy alone	1.386	0.819–2.346	0.224				1.659	1.068–2.577	0.024	1.571	1.010–2.444	0.045
Surgery, n (%)
Optimal surgery	Reference			Reference			Reference
Suboptimal surgery/no surgery	2.167	1.275–3.681	0.004	2.246	1.314–3.840	0.003	1.763	1.077–2.886	0.024	2.086	1.249–3.486	0.005
Metastatic pattern, n (%)
Pleural effusion with positive cytology	Reference						Reference
LNM	0.864	0.421–1.772	0.689				1.291	0.673–2.477	0.443
Others	0.527	0.251–1.105	0.090				0.822	0.424–1.597	0.564
PLT-CA125
0	Reference			Reference			Reference			Reference
1	2.203	1.178–4.119	0.013	2.590	1.356–4.946	0.004	1.553	0949–2.540	0.080	1.751	1.047–2.929	0.033
2	3.580	1.692–7.576	0.001	4.300	1.976–9.358	< 0.001	2.015	1.108–3.665	0.022	2.131	1.146–3.960	0.017

Abbreviations: OS overall survival, PFS progress-free survival, HR hazard ratio, CI confidence interval, HGSC high grade serous carcinoma, Non-HGSC non-high grade serous carcinoma, PDS primary debulking surgery, NACT neoadjuvant chemotherapy, IDS interval debulking surgery, LNM lymph nodes metastasis.beyond abdominopelvic cavity, PLT platelet

ISSN: 1757-2215