Table 3 Subgroup analysis of prognostic factors
Groups | PLT-CA125 | N (%) | OS (months) | PFS (months) | ||||
|---|---|---|---|---|---|---|---|---|
Median (SD) | 95% CI | p | Median (SD) | 95% CI | p | |||
FIGO stage | ||||||||
IVA | 0 | 5 (29.4) | 48.3 (14.6) | 19.6–77.0 | 0.600 | 11.17 | 0.185 | |
1 | 7 (41.2) | 47.4 (13.4) | 21.1–73.7 | 31.8 (13.6) | 5.14–58.5 | |||
2 | 5 (29.4) | 41.7 (10.1) | 21.9–61.5 | 13.3 (5.59) | 2.32–24.2 | |||
IVB | 0 | 34 (37.4) | 90.4 (18.9) | 53.2–127.6 | 0.003 | 32.0 (4.37) | 23.4–40.6 | 0.107 |
1 | 41 (45.1) | 42.7 (2.99) | 36.8–48.5 | 20.0 (3.12) | 13.9–26.1 | |||
2 | 16 (17.6) | 37.8 | 21.2–54.4 | 19.7 (3.15) | 13.5–25.8 | |||
Age | ||||||||
< 55 | 0 | 19 (32.8) | 90.4 (29.2) | 33.2–147.6 | 0.003 | 35.4 (8.95) | 17.9–52.9 | 0.101 |
1 | 25 (43.1) | 42.7 (0.71) | 41.3–44.1 | 21.0 (2.89) | 15.4–26.6 | |||
2 | 14 (24.1) | 40.7 (8.2) | 24.7–47.1 | 16.2 (3.98) | 8.43–24.0 | |||
≧55 | 0 | 20 (40.0) | 70.0 (13.0) | 44.6–95.4 | 0.183 | 32.0 (6.29) | 19.7–44.3 | 0.404 |
1 | 23 (46.0) | 28.7 (9.13) | 10.8–46.6 | 16.9 (5.01) | 7.11–26.7 | |||
2 | 7 (14.0) | 37.8 (8.34) | 21.5–54.1 | 23.9 (3.45) | 18.2–28.4 | |||
Histology | ||||||||
HGSC | 0 | 29 (34.1) | 111.6 (26.6) | 59.4–163.8 | 0.002 | 35.4 (4.45) | 26.69–44.1 | 0.021 |
1 | 39 (45.9) | 42.7 (4.88) | 33.1–52.2 | 20.0 (4.61) | 10.9–29.0 | |||
2 | 17 (20.0) | 41.7 (2.77) | 36.3–47.1 | 21.5 (2.82) | 18.9–27.0 | |||
Non-HGSC | 0 | 10 (43.5) | 20.4 (20.5) | 0.00–60.5 | 0.189 | 9.57 (11.4) | 0.00–31.9 | 0.117 |
1 | 9 (38.3) | 43.2 (5.55) | 32.3–54.1 | 33.5 (15.8) | 2.52–64.5 | |||
2 | 4 (17.4) | 15.6 | 8.83 (2.08) | 4.75–12.9 | ||||
Primary treatment | ||||||||
PDS + chemotherapy | 0 | 21 (39.6) | 90.4 (31.5) | 28.7–152 | 0.009 | 40.1 (3.71) | 32.8–47.3 | 0.104 |
1 | 24 (45.3) | 42.7 (6.04) | 30.8–54.5 | 21.1 (4.42) | 12.4–29.8 | |||
2 | 8 (15.1) | 40.7 (15.7) | 9.87–71.5 | 17.5 (5.47) | 6.79–28.25 | |||
NACT+IDS/ Chemotherapy alone | 0 | 18 (32.7) | 70.0 (29.1) | 12.9–127 | 0.254 | 23.3 (4.97) | 13.6–33.0 | 0.571 |
1 | 24 (45.3) | 43.2 (3.87) | 35.6–50.8 | 20.0 (2.68) | 14.74–25.26 | |||
2 | 13 (23.6) | 37.8 (7.67) | 22.8–52.8 | 19.7 (4.46) | 10.9–28.4 | |||
Surgery | ||||||||
Optimal surgery | 0 | 30 (36.6) | 80.4 (20.2) | 50.8–130 | 0.003 | 32.0 (6.14) | 19.9–44.0 | 0.167 |
1 | 35 (42.7) | 43.9 (3.21) | 37.6–50.2 | 23.6 (6.23) | 11.4–35.8 | |||
2 | 17 (20.7) | 40.7 (10.2) | 20.8–60.6 | 21.5 (6.07) | 11.6–31.4 | |||
Suboptimal surgery/no surgery | 0 | 9 (34.6) | 45.7 (23.6) | 0.00–91.86 | 0.175 | 35.4 (17.4) | 1.37–69.5 | 0.046 |
1 | 13 (50.0) | 23.2 (13.5) | 0.00–49.7 | 12.8 (4.26) | 4.49–21.2 | |||
2 | 4 (15.4) | 37.8 (12.4) | 13.6–62.0 | 12.6 (4.68) | 3.44–21.8 | |||