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Table 2 Effects of the treatment in the groups

From: Effect of phlebotomy versus oral contraceptives containing cyproterone acetate on the clinical and biochemical parameters in women with polycystic ovary syndrome: a randomized controlled trial

 

Phlebotomy

N = 27

P-value*

OCs

N = 30

P-value*

P-value**

3 months post-treatment

Mean difference

3 months post-treatment

Mean difference

BMI

27 (4.7)

−0.01

0.229

25.1 (5.3)

−0.03

0.784

0.355

WHR

0.8 (0.04)

−0.01

0.346

0.7 (0.05)

−0.01

0.621

0.412

Hirsutism score

13.3 (7.4)

−3.7 (6.1)

0.028

9.8 (7.6)

−2.1 (2.8)

0.001

0.235

SBP, (mm Hg)

101.1 (6.5)

−1.1 (10.3)

0.647

102 (8.4)

1.5 (20.1)

0.690

0.610

DBP, (mm Hg)

65.8 (7.7)

−1.7 (10.8)

0.514

65.8 (5.3)

−0.5 (10)

0.780

0.701

HOMA_IR

2.7 (1.2–4.3)

−0.73 (2)

0.047

2.8 (1.8–3.9)

−0.45 (5.6)

0.032

0.516

Insulin, (μU/mL)

8.1 (6.5–15.7)

−0.5 (10.1)

0.025

9.8 (7.8–16.1)

−4.6 (23.8)

0.015

0.512

FAI

4.1 (1.8–8)

−1.1 (3.4)

0.042

3.1 (0.3–6.8)

−1.2 (2.9)

0.001

0.061

Total Testosterone, (ng/mL)

0.42 (0.34)

−0.07 (0.1)

0.047

0.33 (0.1)

−0.06 (0.1)

0.045

0.378

Androstenedione, (ng/mL)

3.3 (1.7)

−1.3 (1.3)

0.026

2.9 (1.6)

−1.1 (1.8)

0.001

0.070

SHBG, (nmol/L)

91.1 (72.4)

55.6 (63)

0.013

163.7 (101.5)

107.06 (115.4)

0.001

0.009

Cholesterol, (mg/dL)

179.8 (67.1)

1.2 (69.4)

0.940

183.2 (41)

3.4 (32.5)

0.076

0.102

Triglycerides, (mg/dL)

123.8 (93.4)

8.3 (83.9)

0.687

152 (89.9)

37.7 (65.1)

0.004

0.019

HDL, (mg/dL)

43 (15.6)

−2.5 (13.9)

0.467

51.9 (15)

4.4 (11.2)

0.053

0.072

LDL, (mg/dL)

93.4 (27)

−2.1 (22.9)

0.709

105.9 (33.4)

8.8 (32.2)

0.150

0.187

AMH, (ng/mL)

8 (5.4)

−0.1 (3.6)

0.909

6.7 (3.8)

−1.9 (5)

0.043

0.191

PSA, (ng/mL)

0.002 (0.002–0.008)

0.003 (0.01)

0.427

0.002 (0.002–0.01)

−0.005 (0.01)

0.204

0.058

  1. Comparison of the parameters with baseline **Comparison of mean differences
  2. Values are given as mean (standard deviation) or median (25%-75%), as appropriate
  3. SBP Systolic blood pressure; DBP Diastolic blood pressure; FAI Free Androgen Index; SHBG Sex Hormone Androgen Index; HOMA-IR Homeostatic Model Assessment for Insulin Resistance; HDL High Density Lipoprotein; LDL Low Density Lipoprotein; AMH Anti Mullerian Hormone; PSA Prostate Specific Antigen; OCs oral contraceptives containing cyproterone acetate