Fig. 3
From: Clarithromycin synergizes with cisplatin to inhibit ovarian cancer growth in vitro and in vivo
CAM increased mitochondrial biogenesis and down-regulated the expression of endogenous antioxidant enzyme expressions in combination with DDP in ovarian cancer cells. a and b C13* cells were treated with DDP, CAM or both, and mitotracker staining was used to track the quantity of mitochondria. Mitotracker staining was much weaker with combined treatment than with DDP or CAM alone. c and d The expression of endogenous antioxidant enzyme SOD1, SOD2, UCP2, Cyto-C, and GPx were detected by qRT-PCR in C13* and SKOV3 cells, respectively. e and f The expression of the key endogenous antioxidant enzyme SOD2 was detected through qRT-PCR in C13* and SKOV3 cells, respectively. Each experiment was performed in triplicate. * P < 0.05