Fig. 5
From: Clarithromycin synergizes with cisplatin to inhibit ovarian cancer growth in vitro and in vivo
CAM-induced apoptosis was associated with endogenous ROS levels generated within mitochondria. a The antioxidant NAC was used to reduce the endogenous ROS levels. C13* cells were treated with DMSO, CAM (20 μM), DDP (80 μM), NAC(10 μM) and the combination of the drugs for 48 h, and apoptosis rates were detected by Annexin V/PI staining. b SKOV3 cells were treated with DMSO, CAM (10 μM), DDP (40 μM), NAC (10 μM), and the combination of the drugs for 48 h, and the apoptosis rates were detected by Annexin V/PI staining. Each experiment was performed in triplicate. * P < 0.05