Fig. 1

Withaferin A decreases the mortality rate and body composition changes associated with ovarian cancer. (a) Body weight fold change of control, vehicle treated, WFA 2 mg/kg, and WFA 6 mg/kg groups over the period of the study. N = 5 in each group. (b) Kaplan-Meier survival analysis. Letters A and B are used to delineate groups with respect to statistical significance (A = control and WFA 2 mg/kg; B = WFA 4 mg/kg and vehicle treated). (c) Representative DEXA scan images of control, vehicle treated, WFA 2 mg/kg, and WFA 6 mg/kg mice. Area within dashed box surrounding image is the same. Quantitative estimation of whole body DEXA scan minus head ROI of (d) adipose tissue and (e) lean tissue as a percentage of body weight. (f) Average weight of visible tumors in the peritoneum. N = 5 (control), 4 (vehicle treated), 5 (WFA 2 mg/kg), and 4 (WFA 6 mg/kg). Opaque black circles indicate individual data points. *P < 0.05; **p < 0.01; ***p < 0.001, value significantly different from corresponding value of control group as determined by one-way ANOVA followed by Tukey’s HSDT. ^#P < 0.05, value significantly different from corresponding value of vehicle treated group. ^$P < 0.05, value significantly different from corresponding value of WFA 2 mg/kg group