Fig. 1

Schematic overview of the WNT signaling pathway. Wnt binds to (triggers) the receptor. Axin is removed from the “destruction complex.” β-catenin transfers into the nucleus, binds to a transcription factor on DNA, and stimulates transcription of a protein. Binding of Wnt to the receptors Frizzled (Fz) and LRP6 primes to inhibition of β-catenin degradation. β-catenin in turn interrelates with members of the TCF/Lef-1 family of transcription factors to co-activate target gene transcription