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Table 1 Literature review of all previous cases of false elevations of AFP in non-seminomatous GCTs

From: Persistently elevated alpha-fetoprotein associated with chronic hepatitis B during chemotherapy for malignant ovarian germ cell tumors: a case series and a review of the literature

Author/Year of publicationCaseAgeHistologic typeStageMaximum AFP level (ng/ml)EtiologyAdditional treatmentOutcome
Germa et al. 1993 [26]a1e26YSTIII122HD (anesthetic drugs)Second surgeryANED
228S, EC, YSTIII16HD (HCV, alcohol)ANED
329EC, TII91HD (chemotherapeutic drugs)ANED
417EC, T, YSTIV42HD (chemotherapeutic drugs)ANED
530ECII18HD (antiepileptic drugs)ANED
627S, EC, YSTII155HD (HBV)ANED
723S, EC, TII13HD (alcohol)ChemoANED
821S, ITIV120HD (alcohol)ANED
Morris et al. 2000 [35]b933ECI40NAANED
1024EC, TII55NAANED
1122S, CCI107HD (early cirrhosis)NA
Funahashi et al. 2005 [31]c
Wymer et al. 2017 [18]d
1230S, T, ITI20NAANED
1330TI18NAANED
1435EC, YST, TI11NAANED
1528EC, YST, TII13NAANED
1618EC, YST, TI11NAChemoANED
1732T, EC, CCI15.8NAChemoANED
1821ECI9.4NAPRLNDANED
  1. ANED Alive with no evidence of disease, CC Choriocarcinoma, Chemo Chemotherapy, EC Embryonal carcinoma, HD Hepatic dysfunction, IT Immature teratoma, NA Not available, PRLND Retroperitoneal lymphadenectomy, S Seminoma, T Teratoma, YST Yolk sac tumor.
  2. a, b, c One case in each article is seminoma, respectively
  3. d Four cases in the article is seminoma
  4. e All the patients are male, except this patient is female