Fig. 3

Circ_0078607 directly bound to miR-518a-5p in ovarian cancer cells. a Relative expression level of miR-518a-5p and miR-527 were detected by qRT-PCR in 20 ovarian cancer tissues and paired adjacent normal tissues. b Bivariate correlation analysis of the relationship between circ_0078607 and miR-518a-5p expression level. c The seed sequences of circ_0078607WT/Mut and miR-518a-5p. d Dual-luciferase reporter assays were performed to detect the correlation between miR-518a-5p and circ_0078607. e MiR-518a-5p promoted the proliferation of SKOV3 and A2780 cells. f MiR-518a-5p mimic functionally restored circ_0078607 overexpression-suppressed ovarian cancer cells proliferation. Error bars represent mean ± standard deviation (SD). *p < 0.05, **p < 0.01, ***p < 0.001