Fig. 7

B.coccineus ethanol leaf extract induces cell cycle arrest and apoptosis via the p53 dependent pathway. As illustrated in model, p53 acts as transcription factor to regulate both apoptosis and cell cycle signalling cascade. The cell cycle progression is controlled by four phases: G1 or gap 1 phase , S or synthesis phase, G2 or gap2 phase and M or mitosis phase. Altogether, treating ovarian cancer cells with B.coccineus ethanol leaf extract could inhibit the cell proliferation, and increase an overall survival of patients