Bioinformatics analysis of gene expression profile of serous ovarian carcinomas to screen key genes and pathways

Table 3 Co-occurrence or mutual exclusive alterations of 4 hub genes

Gene A	Gene B	p-value	Log odds ratio	Association
KIF11	CDC20	0.008	1.971	Tendency towards co-occurrence
KIF11	TOP2A	0.039	2.269	Tendency towards co-occurrence
CDC20	PBK	0.326	0.440	Tendency towards co-occurrence
KIF11	PBK	0.492	0.350	Tendency towards co-occurrence
PBK	TOP2A	0.559	−0.610	Tendency towards mutual exclusivity
CDC20	TOP2A	0.592	−0.229	Tendency towards mutual exclusivity

The query contains 2 gene pairs with mutually exclusive alterations (no significant), and 4 gene pairs with co-occurrent alterations (2 significant)
Log odds ratio > 0: Association towards co-occurrence
Log odds ratio < = 0: Association towards mutual exclusivity
P-value < 0.05: Significant association
P-value: Derived from Fisher Exact Test
Log odds ratio: Quantifies how strongly the presence or absence of alterations in gene A are associated with the presence or absence of alterations in gene B in the selected tumors

ISSN: 1757-2215