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Table 4 Test efficiency of the Modified Ovarian Sensitivity Index for in vitro fertilization parameters (additional cohort)

From: Initial ovarian sensitivity index predicts embryo quality and pregnancy potential in the first days of controlled ovarian stimulation

Category MOSI score All data (n = 337) Only normo-responders (n = 255)
Prevalence Test accuracy PPV NPV Prevalence Test accuracy PPV NPV
High-quality Embryo on Day 2 (≥6) 2.1 27.3% 33.2% 28.6% 88.5% 27.1% 27.1% 27.1% N/A
2.6   43.4% 32.0% 93.5%   35.7% 29.4% 95.8%
3.1   54.3% 36.0% 89.6%   50.2% 33.7% 88.3%
3.6   68.5% 45.2% 86.4%   69.0% 45.1% 85.0%
4.1   71.8% 47.1% 76.2%   73.3% 57.1% 73.8%
4.6   71.5% 16.7% 72.5%   72.9% N/A 72.9%
Blastocysts (≥6) 2.0 35.9% 39.5% 36.9% 80.0% 35.7% 35.7% 35.7% N/A
2.5   44.8% 39.1% 89.5%   35.7% 35.7% N/A
3.0   54.9% 43.4% 81.4%   49.0% 39.8% 76.6%
3.5   68.0% 54.0% 80.7%   66.3% 52.1% 78.3%
4.0   69.4% 64.1% 70.7%   68.2% 75.0% 67.7%
4.5   65.3 70.0% 65.1%   64.3% N/A 64.3%
Rate of blastocyst/ova captured (≥35%) 2.0 18.1% 22.8% 18.6% 90.0% 18.0% 18.0% 18.0% N/A
2.5   28.2% 19.7% 94.7%   18.0% 18.0% N/A
3.0   43.0% 22.1% 91.2%   37.6% 20.4% 89.1%
3.5   61.4% 28.6% 91.5%   62.0% 28.2% 90.6%
4.0   74.8% 31.3% 85.0%   79.6% 35.0% 83.4%
4.5   80.7% 30.0% 82.3%   82.0% N/A 82.0%
4.8   81.3% 0% 81.8%   82.0% N/A 82.0%
  1. Abbreviations: MOSI modified ovarian sensitivity index, NPV negative predictive value, and PPV Positive predictive value
  2. Bold values are the results based on the cutoff using the highest Youden index based on the Receiver-operating characteristic curve