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Table 4 Test efficiency of the Modified Ovarian Sensitivity Index for in vitro fertilization parameters (additional cohort)

From: Initial ovarian sensitivity index predicts embryo quality and pregnancy potential in the first days of controlled ovarian stimulation

Category

MOSI score

All data (n = 337)

Only normo-responders (n = 255)

Prevalence

Test accuracy

PPV

NPV

Prevalence

Test accuracy

PPV

NPV

High-quality Embryo on Day 2 (≥6)

2.1

27.3%

33.2%

28.6%

88.5%

27.1%

27.1%

27.1%

N/A

2.6

 

43.4%

32.0%

93.5%

 

35.7%

29.4%

95.8%

3.1

 

54.3%

36.0%

89.6%

 

50.2%

33.7%

88.3%

3.6

 

68.5%

45.2%

86.4%

 

69.0%

45.1%

85.0%

4.1

 

71.8%

47.1%

76.2%

 

73.3%

57.1%

73.8%

4.6

 

71.5%

16.7%

72.5%

 

72.9%

N/A

72.9%

Blastocysts (≥6)

2.0

35.9%

39.5%

36.9%

80.0%

35.7%

35.7%

35.7%

N/A

2.5

 

44.8%

39.1%

89.5%

 

35.7%

35.7%

N/A

3.0

 

54.9%

43.4%

81.4%

 

49.0%

39.8%

76.6%

3.5

 

68.0%

54.0%

80.7%

 

66.3%

52.1%

78.3%

4.0

 

69.4%

64.1%

70.7%

 

68.2%

75.0%

67.7%

4.5

 

65.3

70.0%

65.1%

 

64.3%

N/A

64.3%

Rate of blastocyst/ova captured (≥35%)

2.0

18.1%

22.8%

18.6%

90.0%

18.0%

18.0%

18.0%

N/A

2.5

 

28.2%

19.7%

94.7%

 

18.0%

18.0%

N/A

3.0

 

43.0%

22.1%

91.2%

 

37.6%

20.4%

89.1%

3.5

 

61.4%

28.6%

91.5%

 

62.0%

28.2%

90.6%

4.0

 

74.8%

31.3%

85.0%

 

79.6%

35.0%

83.4%

4.5

 

80.7%

30.0%

82.3%

 

82.0%

N/A

82.0%

4.8

 

81.3%

0%

81.8%

 

82.0%

N/A

82.0%

  1. Abbreviations: MOSI modified ovarian sensitivity index, NPV negative predictive value, and PPV Positive predictive value
  2. Bold values are the results based on the cutoff using the highest Youden index based on the Receiver-operating characteristic curve