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Table 2 Univariate and multivariate analysis of prognostic factors

From: The survival effect of ovary preservation in early stage endometrial cancer: a single institution retrospective analysis

variables

Overall survival

Recurrence Free survival

Adjusted modela

Multivariableb

Adjusted modela

Multivariableb

HR(95% CI)

 

HR(95% CI)

 

HR(95% CI)

 

HR(95% CI)

 

N = 539/EVNET = 31

p-value

N = 539/EVNET = 31

p-value

N = 539/EVNET = 33

p-value

N = 539/EVNET = 33

p-value

Ovary

 preserved

1(ref)

   

1(ref)

   

 removed

2.058 (0.266–15.915)

0.4892

  

0.865 (0.245–3.052)

0.8215

  

FIGO grade

 1

1(ref)

0.0103

  

1(ref)

0.0339

  

 2

2.305 (0.869–6.116)

0.0935

  

2.418 (1.052–5.556)

0.0376

  

 3

4.215 (1.324–13.42)

0.0149

  

1.176 (0.255–5.416)

0.8355

  

 etc

5.102 (1.838–14.162)

0.0018

  

3.807 (1.465–9.894)

0.0061

  

Histology

 Endometrioid

1(ref)

0.0013

1(ref)

0.0006

1(ref)

0.0322

  

 Serous

5.333 (2.206–12.892)

0.0002

5.969 (2.437–14.617)

<.0001

3.548 (1.389–9.062)

0.0081

  

 CCC

3.381 (0.968–11.806)

0.0562

3.729 (1.064–13.072)

0.0397

3.031 (0.894–10.274)

0.075

  

 Mucinous/mixed/Undifferentiated/NE/etc

3.212 (0.921–11.196)

0.067

3.373 (0.963–11.808)

0.0572

1.609 (0.374–6.918)

0.5224

  

approach

 Laparoscopy

1(ref)

0.027

  

1(ref)

0.4568

  

 Laparotomy

2.298 (1.058–4.992)

0.0355

  

1.604 (0.765–3.36)

0.2106

  

 etc

7.88 (0.974–63.726)

0.0529

  

–

0.9883

  

Hysterectomy - radicality

 A

1(ref)

0.2591

  

1(ref)

0.9624

  

 B

–

0.9901

  

0.598 (0.073–4.913)

0.6322

  

 C

0.443 (0.091–2.159)

0.3139

  

0.776 (0.162–3.704)

0.7503

  

 Not done

6.183 (0.769–49.733)

0.0868

  

–

0.9887

  

PLND

 No

1(ref)

   

1(ref)

   

 Yes

0.371 (0.162–0.852)

0.0194

  

0.549 (0.24–1.256)

0.1556

  

PALND

 No

1(ref)

   

1(ref)

   

 Yes

0.848 (0.407–1.766)

0.6593

  

1.008 (0.491–2.068)

0.9826

  

Adjuvant chemotherapy

 No

1(ref)

 

1(ref)

 

1(ref)

 

1(ref)

 

 Yes

2.083 (0.969–4.477)

0.0602

0.318 (0.137–0.736)

0.0074

2.864 (1.396–5.873)

0.0041

3.414 (1.649–7.069)

0.0009

Adjuvant radiotherapy

 No

1(ref)

   

1(ref)

 

1(ref)

 

 Yes

0.659 (0.249–1.744)

0.4006

  

2.655 (1.163–6.059)

0.0204

3.256 (1.428–7.423)

0.005

  1. CCC clear cell carcinoma, NE neuroendocrine tumor, PLND pelvic lymph-node dissection, PALND para-aortic lymph node dissection
  2. a Adjusted model: adjuted age at diagnosis (≤50 vs > 50), FIGO stage
  3. b Multivariableb: adjuted age at diagnosis (≤50 vs > 50), FIGO stage
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Journal of Ovarian Research

ISSN: 1757-2215

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