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Table 2 Univariate and multivariate analysis of prognostic factors

From: The survival effect of ovary preservation in early stage endometrial cancer: a single institution retrospective analysis

variables Overall survival Recurrence Free survival
Adjusted modela Multivariableb Adjusted modela Multivariableb
HR(95% CI)   HR(95% CI)   HR(95% CI)   HR(95% CI)  
N = 539/EVNET = 31 p-value N = 539/EVNET = 31 p-value N = 539/EVNET = 33 p-value N = 539/EVNET = 33 p-value
Ovary
 preserved 1(ref)     1(ref)    
 removed 2.058 (0.266–15.915) 0.4892    0.865 (0.245–3.052) 0.8215   
FIGO grade
 1 1(ref) 0.0103    1(ref) 0.0339   
 2 2.305 (0.869–6.116) 0.0935    2.418 (1.052–5.556) 0.0376   
 3 4.215 (1.324–13.42) 0.0149    1.176 (0.255–5.416) 0.8355   
 etc 5.102 (1.838–14.162) 0.0018    3.807 (1.465–9.894) 0.0061   
Histology
 Endometrioid 1(ref) 0.0013 1(ref) 0.0006 1(ref) 0.0322   
 Serous 5.333 (2.206–12.892) 0.0002 5.969 (2.437–14.617) <.0001 3.548 (1.389–9.062) 0.0081   
 CCC 3.381 (0.968–11.806) 0.0562 3.729 (1.064–13.072) 0.0397 3.031 (0.894–10.274) 0.075   
 Mucinous/mixed/Undifferentiated/NE/etc 3.212 (0.921–11.196) 0.067 3.373 (0.963–11.808) 0.0572 1.609 (0.374–6.918) 0.5224   
approach
 Laparoscopy 1(ref) 0.027    1(ref) 0.4568   
 Laparotomy 2.298 (1.058–4.992) 0.0355    1.604 (0.765–3.36) 0.2106   
 etc 7.88 (0.974–63.726) 0.0529    0.9883   
Hysterectomy - radicality
 A 1(ref) 0.2591    1(ref) 0.9624   
 B 0.9901    0.598 (0.073–4.913) 0.6322   
 C 0.443 (0.091–2.159) 0.3139    0.776 (0.162–3.704) 0.7503   
 Not done 6.183 (0.769–49.733) 0.0868    0.9887   
PLND
 No 1(ref)     1(ref)    
 Yes 0.371 (0.162–0.852) 0.0194    0.549 (0.24–1.256) 0.1556   
PALND
 No 1(ref)     1(ref)    
 Yes 0.848 (0.407–1.766) 0.6593    1.008 (0.491–2.068) 0.9826   
Adjuvant chemotherapy
 No 1(ref)   1(ref)   1(ref)   1(ref)  
 Yes 2.083 (0.969–4.477) 0.0602 0.318 (0.137–0.736) 0.0074 2.864 (1.396–5.873) 0.0041 3.414 (1.649–7.069) 0.0009
Adjuvant radiotherapy
 No 1(ref)     1(ref)   1(ref)  
 Yes 0.659 (0.249–1.744) 0.4006    2.655 (1.163–6.059) 0.0204 3.256 (1.428–7.423) 0.005
  1. CCC clear cell carcinoma, NE neuroendocrine tumor, PLND pelvic lymph-node dissection, PALND para-aortic lymph node dissection
  2. a Adjusted model: adjuted age at diagnosis (≤50 vs > 50), FIGO stage
  3. b Multivariableb: adjuted age at diagnosis (≤50 vs > 50), FIGO stage