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Table 1 The Characteristics and Newcastle–Ottawa scale score of studies included in the meta-analysis

From: Can polymorphisms of AMH/AMHR2 affect ovarian stimulation outcomes? A systematic review and meta-analysis

Study

Country/Ethnicity

SNPs evaluated

No. of patients

Mean age ± SD

Protocol

Study design

Genotyping

HWE

Outcomes*

NOS scores

Lledó, 2019 [18]

Spain/Caucasian

AMH/ AMHR2

124

23.9 ± 3.5

GnRH-A

prospective

PCR

Yes

1.2.3

6

Wu, 2019 [21]

China/Asian

AMH/AMHR2

635

NA

GnRHa

prospective

PCR

Yes

1.2.3.4.7

6

Lazaros, 2016 [17]

Greece/Caucasian

AMHR2

300

28–38

GnRHa

prospective

PCR

Yes

3. 4.

7

Cerra, 2016 [15]

UK/multiple

AMH/AMHR2

603

NA

GnRHa/GnRH-A

prospective

TaqMan

No metion

2. 3. 5. 8

6

Peluso, 2015 [19]

Brazil

AMH/AMHR2

186

32.5 ± 3.5

GnRH-A

prospective

TaqMan

Yes

3. 6. 7. 8.

6

Wang, 2015 [20]

China/Asian

AMH

122

NA

GnRHa

retrospective

PCR

Yes

3

7

Karagiorga, 2015 [16]

Greece

AMH/AMHR2

151

36 ± 5

GnRHa/GnRH-A

prospective

PCR

Yes

1. 2. 3. 4.

7

  1. *Outcomes: 1. stimulation duration; 2. Gn dosage; 3. No. of oocytes retrieved; 4. clinical pregnancy rate; 5. live birth; 6. AMH level; 7. No. of MII oocytes; 8. No. of embryo. HWE Hardy-Weinberg equilibrium