Table 2 Ovarian cancer etiology related upregulated and downregulated miRNAs and target proteins in monozygotic twins
miRNAs | Fold change (FC) values | Sequence of miRNA | miRNAStatus | Target genes |
|---|---|---|---|---|
miR-1273 g-3p | 3,57 | ACCACUGCACUCCAGCCUGAG | Upregulated | ZNF138, TMEM239, BMP3 |
miR-1305 | 2,05 | UUUUCAACUCUAAUGGGAGAGA | Upregulated | PTPN4, PRKAA1, PAPD7, FRAT2, DEPDC1, FBXO41 |
miR-197-3p | 2,7 | UUCACCACCUUCUCCACCCAGC | Upregulated | CD82, PMAIP1, MTHFD1, CHECK1, AGO1, CASP10 |
miR-3651 | 2,17 | CAUAGCCCGGUCGCUGGUACAUGA | Upregulated | RACGAP1, OLA1, TEX261, PTGS1, NFIC, ZNF200 |
miR-6131 | 2,22 | GGCUGGUCAGAUGGGAGUG | Upregulated | PAGR1, IGF2BP1, CACNG8 |
miR-92a-3p | 2,09 | UAUUGCACUUGUCCCGGCCUGU | Upregulated | STAT3, PTEN, ATM, NOTCH2, CDH1, NFKB1 |
let-7i-5p | −2,45 | UGAGGUAGUAGUUUGUGCUGUU | Downregulated | TLR4, BMP4, EIF2C1, NEUROG1, SOCS1, IGF1 |
miR-125a-5p | -5,96 | UCCCUGAGACCCUUUAACCUGUGA | Downregulated | ERBB3, CDKN1A, TP53, ERBB2, EGFR, STAT3,MYC, VEGFA |
miR-15b-5p | -3,61 | UAGCAGCACAUCAUGGUUUACA | Downregulated | BCL2, VEGFA, CCND1, CCNE1, CDK1, CDK4, CDK6, E2F3, MAPK1 |
miR-22-3p | -8,92 | AAGCUGCCAGUUGAAGAACUGU | Downregulated | CDKN1A, WNT1, ERBB3, MYCBP, HMGB1, E2F2, PTEN, POTED, SOD2, |
miR-3135b | -4,38 | GGCUGGAGCGAGUGCAGUGGUG | Downregulated | BIRC5, ABL2, MAPK1, MYCN |
miR-320d | -2,01 | AAAAGCUGGGUUGAGAGGA | Downregulated | DCTN5, SYNCRIP, FBXO28 |
miR-342-3p | -2,36 | UCUCACACAGAAAUCGCACCCGU | Downregulated | GEMIN4, DNMT1, ID4, SREBF1,SREBF2, BMP7 |
miR-4430 | -2,01 | AGGCUGGAGUGAGCGGAG | Downregulated | ZNF485,ABL2, MAPK1, MSH5, PTEN |
miR-451a | -12,89 | AAACCGUUACCAUUACUGAGUU | Downregulated | CPNE3, RAB5A, IL6R, AKT1, MMP2 |
miR-664b-5p | -3,21 | UGGGCUAAGGGAGAUGAUUGGGUA | Downregulated | CD55,MSN, RHOBTB3, PLAG1 |
miR-766-3p | -2,02 | ACUCCAGCCCCACAGCCUCAGC | Downregulated | COX1, MAPK1, NF2, RAD51, STK4, STK24, VEGFC |