Table 5 Epithelial ovarian cancer predisposition associated upregulated and downregulated miRNAs, target molecules. An additional table file shows this in more detail [see Additional file 3].
miRNAs | Fold change (FC) values | Sequence of miRNA | miRNAStatus | Target genes |
|---|---|---|---|---|
let-7a-5p | 10,8 | UGAGGUAGUAGGUUGUAUAGUU | Upregulated | NF2,KRAS,HMGA2,HMGA1,CDK6, NRAS |
let-7b-5p | 3,79 | UGAGGUAGUAGGUUGUGUGGUU | Upregulated | HMGA1, IGF2BP1, CDC34, HMGA2, CDC25A, IGF2BP2 |
miR-181a-5p | 3,2 | AACAUUCAACGCUGUCGGUGAGU | Upregulated | CDKN1B,ATM,BCL2,KRAS, MAPK1 BRCA1,CDH13,KRAS,MMP14, NOTCH1, NOTCH2 |
miR-197-3p | 2,8 | UUCACCACCUUCUCCACCCAGC | Upregulated | CD82, PMAIP1, MTHFD1, RAD51, AGO1, CASP10, CHECK1 |
miR-21-5p | 6,75 | UAGCUUAUCAGACUGAUGUUGA | Upregulated | CDC25A,BCL2, PTEN, APAF1, E2F1, TP53, MSH2 |
miR-223-3p | 6,55 | UGUCAGUUUGUCAAAUACCCCA | Upregulated | IGF1R, PARP1 E2F1,CDK2, ATM, STAT5A, E2F1 |
miR-23a-3p | 5,98 | AUCACAUUGCCAGGGAUUUCC | Upregulated | MYH1,MYH2,MYH4,PTEN, APAF1, FOXO3, CDH1, MYC |
miR-27a-3p | 17,2 | UUCACAGUGGCUAAGUUCCGC | Upregulated | FOXO1, SP1, APC, EGFR, CCND1, CDH6, NF1, NRAS, TP53, WNT9B |
miR-3653-3p | 3,3 | CUAAGAAGUUGACUGAAG | Upregulated | CCND2, MYLIP, MTMR4, SMAD5, PTEN |
miR-425-5p | 6,08 | AAUGACACGAUCACUCCCGUUGA | Upregulated | CCND1, PTEN, FGFR3, DICER1, E2F3, MAP2K6, NRAS |
miR-572 | 3,34 | GUCCGCUCGGCGGUGGCCCA | Upregulated | CDKN1A, MED29, WNT7A, ATM |
miR-574-5p | 3,46 | UGAGUGUGUGUGUGUGAGUGUGU | Upregulated | FOXN3, PPP2R1B, BCL10, CCND1, CDH12, CDK15, CDKN1A, MAPK10 |
miR-6127 | 2,32 | UGAGGGAGUGGGUGGGAGG | Upregulated | TUBB2A,MYH14, DLX6, HIP, CHRDL1 |
miR-7641 | 3,14 | UUGAUCUCGGAAGCUAAGC | Upregulated | TRIP4,TAOK1,ARL5C,COX20, PPWD1, SLC30A4 |
let-7i-5p | −11,7 | UGAGGUAGUAGUUUGUGCUGUU | Downregulated | TLR4, BMP4, EIF2C1, NEUROG1, SOCS1, IL13, IGF1 |
miR-125a-5p | −4,11 | UCCCUGAGACCCUUUAACCUGUGA | Downregulated | ERBB3, CDKN1A, TP53, ERBB2, EGFR, STAT3, MYC, VEGFA |
miR-15b-5p | −3,08 | UAGCAGCACAUCAUGGUUUACA | Downregulated | BCL2,VEGFA,CCND1,CCNE1, CDK1, CDK4, CDK6, E2F3, MAPK1 |
miR-150-5p | −2,77 | UCUCCCAACCCUUGUACCAGUG | Downregulated | EGR2, ZEB1, MUC4,MYB, TP53, BIRC5 |
miR − 22-3p | −2,99 | AAGCUGCCAGUUGAAGAACUGU | Downregulated | CDKN1A, WNT1, ERBB3, MYCBP, HMGB1, BMP6, E2F2, PTEN |
miR-328-3p | −2,17 | CUGGCCCUCUCUGCCCUUCCGU | Downregulated | CD44, MMP16, AGO1, RAD51 |
miR-4430 | -2,35 | AGGCUGGAGUGAGCGGAG | Downregulated | ZNF485, ABL2, MAPK1, MSH5,PTEN |
miR-451a | −37,8 | AAACCGUUACCAUUACUGAGUU | Downregulated | CPNE3, RAB5A, IL6R, AKT1, MMP2 |
miR-4697 − 5p | -5,5 | AGGGGGCGCAGUCACUGACGUG | Downregulated | SIX5, BCL7A, MEN1,VGF |
miR-664b-5p | −2,89 | UGGGCUAAGGGAGAUGAUUGGGUA | Downregulated | CD55, MSN, RHOBTB3, PLAG1 |
miR-766-3p | −2,5 | ACUCCAGCCCCACAGCCUCAGC | Downregulated | COX1, MAPK1, NF2, RAD51, STK4, STK24, VEGFC |