Table 5 Detailed information of drugs listed in Table 4
Targeted genes | Drugs | Discription | FDA status | Associated Conditions |
|---|---|---|---|---|
DUSP1 ETV4 FOXQ1 IL6 SERPINE1 | Selumetinib | selumetinib are important tools that can target the problematic overactivity of Raf-MEK-ERK signaling pathway. | Approved, Investigational | NA |
AQP5 CD40 DUSP1 IL6 SERPINE1 | Dolastatin 10 | Dolastatin 10 has been used in trials studying the treatment of Sarcoma, Leukemia, Lymphoma, Liver Cancer, and Kidney Cancer, among others. | Investigational | NA |
CD40 CXCR4 IL6 SERPINE1 | Ixabepilone | Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. | Approved, Investigational | Locally Advanced Breast Cancer (LABC) Metastatic Breast Cancer |
CXCR4 IL6 NPW SERPINE1 | Vorinostat | Vorinostat (rINN) or suberoylanilide hydroxamic acid (SAHA), is a drug currently under investigation for the treatment of cutaneous T cell lymphoma (CTCL) | Approved, Investigational | Persistent Cutaneous T-Cell Lymphoma Progressive Cutaneous T-cell lymphoma Recurrent Cutaneous T-cell lymphoma |
Belinostat | Belinostat is a novel agent that inhibits the enzyme histone deacetylase (HDAC) with a sulfonamide-hydroxamide structure. | Approved, Investigational | Relapsed Peripheral T-Cell Lymphoma Refractory Peripheral T-cell Lymphoma Unspecified | |
CD40 DUSP1 IL6 SERPINE1 | Vinorelbine | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies | Approved, Investigational | Advanced Non Small Cell Lung Cancer Esophageal Cancers Locally Advanced Non-Small Cell Lung Cancer Metastatic Breast Cancer Recurrent Cervical Cancer Soft Tissue Sarcoma (STS) Recurrent, IV-B Cervical cancer |
Tamoxifen | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations | Approved | Breast Cancer Desmoid Tumors Endometrial Cancer Gynecomastia Invasive Breast Cancer Invasive Breast Carcinoma Metastatic Breast Cancer Ovarian Cancer Puberty, Precocious | |
CD40 CXCR4 DUSP1 SERPINE1 | Raloxifene | Raloxifene is a second generation selective estrogen receptor modulator (SERM) that mediates anti-estrogenic effects on breast and uterine tissues, and estrogenic effects on bone, lipid metabolism, and blood coagulation. | Approved, Investigational | Invasive Breast Cancer Osteoporosis Osteoporosis caused by glucocorticoid |
DUSP1 ETV4 IL6 SERPINE1 | Tanespimycin | Tanespimycin, manufactured by Conforma Therapeutics is under development as a small molecule inhibitor of heat shock protein 90 (HSP90). It is developed for the treatment of several types of cancer, solid tumors or chronic myelogenous leukemia. | Investigational | NA |
DUSP1 ETV4 SERPINE1 SPP1 | Dabrafenib | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. | Approved, Investigational | Metastatic Melanoma Unresectable Melanoma |