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Table 5 Detailed information of drugs listed in Table 4

From: Integrative analysis of the common genetic characteristics in ovarian cancer stem cells sorted by multiple approaches

Targeted genes Drugs Discription FDA status Associated Conditions
DUSP1 ETV4 FOXQ1 IL6 SERPINE1 Selumetinib selumetinib are important tools that can target the problematic overactivity of Raf-MEK-ERK signaling pathway. Approved, Investigational NA
AQP5 CD40 DUSP1 IL6 SERPINE1 Dolastatin 10 Dolastatin 10 has been used in trials studying the treatment of Sarcoma, Leukemia, Lymphoma, Liver Cancer, and Kidney Cancer, among others. Investigational NA
CD40 CXCR4 IL6 SERPINE1 Ixabepilone Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. Approved, Investigational Locally Advanced Breast Cancer (LABC)
Metastatic Breast Cancer
CXCR4 IL6 NPW SERPINE1 Vorinostat Vorinostat (rINN) or suberoylanilide hydroxamic acid (SAHA), is a drug currently under investigation for the treatment of cutaneous T cell lymphoma (CTCL) Approved, Investigational Persistent Cutaneous T-Cell Lymphoma
Progressive Cutaneous T-cell lymphoma
Recurrent Cutaneous T-cell lymphoma
Belinostat Belinostat is a novel agent that inhibits the enzyme histone deacetylase (HDAC) with a sulfonamide-hydroxamide structure. Approved, Investigational Relapsed Peripheral T-Cell Lymphoma
Refractory Peripheral T-cell Lymphoma Unspecified
CD40 DUSP1 IL6 SERPINE1 Vinorelbine Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies Approved, Investigational Advanced Non Small Cell Lung Cancer
Esophageal Cancers
Locally Advanced Non-Small Cell Lung Cancer
Metastatic Breast Cancer
Recurrent Cervical Cancer
Soft Tissue Sarcoma (STS)
Recurrent, IV-B Cervical cancer
Tamoxifen Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations Approved Breast Cancer
Desmoid Tumors
Endometrial Cancer
Gynecomastia
Invasive Breast Cancer
Invasive Breast Carcinoma
Metastatic Breast Cancer
Ovarian Cancer
Puberty, Precocious
CD40 CXCR4 DUSP1 SERPINE1 Raloxifene Raloxifene is a second generation selective estrogen receptor modulator (SERM) that mediates anti-estrogenic effects on breast and uterine tissues, and estrogenic effects on bone, lipid metabolism, and blood coagulation. Approved, Investigational Invasive Breast Cancer
Osteoporosis
Osteoporosis caused by glucocorticoid
DUSP1 ETV4 IL6 SERPINE1 Tanespimycin Tanespimycin, manufactured by Conforma Therapeutics is under development as a small molecule inhibitor of heat shock protein 90 (HSP90). It is developed for the treatment of several types of cancer, solid tumors or chronic myelogenous leukemia. Investigational NA
DUSP1 ETV4 SERPINE1 SPP1 Dabrafenib Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. Approved, Investigational Metastatic Melanoma
Unresectable Melanoma