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Table 1 Performed studies on curcumin and EC therapy

From: Therapeutic role of curcumin and its novel formulations in gynecological cancers

Type of curcumin Dose Target(s) Effect(s) Type of cell line Ref
Curcumin 6 μM CTGF, MMP-2, -9
Slit-2, CXCR4, SDF-1, MMP9
Induction of apoptosis
Inhibition of tumor proliferation, migration, invasion, and growth
Ishikawa
Hec-1B
[32]
  6 μM for 48h - Induction of ROS production Ishikawa cell [32]
  50 mg/kg - Reduction the tumor volume in mice - [32]
  30 μmol/L MMP-2 Curcumin can suppress invasion and proliferation of endometrial cancer cell Ishikawa [35]
  50 μM STAT-3
PIAS-3
Curcumin can inhibit JAK-STAT signaling through PIAS-3 activation RL95-2
Ishikawa
OVCA cell
[36]
  30 μM for 120h TREK1 Curcumin has an antiproliferative effect on endometrial cells. Ishikawa [37]
  30 μM MMP-2, -9
ERK
Curcumin can suppress invasion and proliferation of endometrial cancer cells through inhibition of MMP-2 and MMP-9 and the ERK signaling pathway HEC-1B [21]
  300 mg/kg.d Bcl-2 Curcumin inhibits the Bcl-2 expression - [38]
  40 to 60 μM
for 3h
Ets-1
Bcl-2
Curcumin can decrease the Bcl-2 and Ets-1 expression and induces apoptosis. HEC-1-A [39]
  100 μM/L Androgen receptor (AR) Curcumin can suppress apoptosis and proliferation of endometrial cancer cells through decreasing expression of androgen receptor NA [34]
  112.5 μM - Curcumin has an antiproliferative effect on MCF-7, MG-63 and MDA-MB-231 cells MDA-MB-231
MCF-7
MG-63
[40]
Curcumin loaded amphiphilic mixed micelles 10 μM Survivin
Bcl-2
PARP
Inhibition of tumor growth,
Apoptosis induction
Ishikawa [41]
Liposomal Curcumin NA NF-κB Inhibition of tumor growth Ishikawa
HEC-1
[42]
Curcumin Phytosome 2 g/day - Immunomodulatory effects - [43]