Table 1 Performed studies on curcumin and EC therapy

Curcumin

6 μM

CTGF, MMP-2, -9

Slit-2, CXCR4, SDF-1, MMP9

Induction of apoptosis

Inhibition of tumor proliferation, migration, invasion, and growth

Ishikawa

Hec-1B

[32]

6 μM for 48h

-

Induction of ROS production

Ishikawa cell

[32]

50 mg/kg

-

Reduction the tumor volume in mice

-

[32]

30 μmol/L

MMP-2

Curcumin can suppress invasion and proliferation of endometrial cancer cell

Ishikawa

[35]

50 μM

STAT-3

PIAS-3

Curcumin can inhibit JAK-STAT signaling through PIAS-3 activation

RL95-2

Ishikawa

OVCA cell

[36]

30 μM for 120h

TREK1

Curcumin has an antiproliferative effect on endometrial cells.

Ishikawa

[37]

30 μM

MMP-2, -9

ERK

Curcumin can suppress invasion and proliferation of endometrial cancer cells through inhibition of MMP-2 and MMP-9 and the ERK signaling pathway

HEC-1B

[21]

300 mg/kg.d

Bcl-2

Curcumin inhibits the Bcl-2 expression

-

[38]

40 to 60 μM

for 3h

Ets-1

Bcl-2

Curcumin can decrease the Bcl-2 and Ets-1 expression and induces apoptosis.

HEC-1-A

[39]

100 μM/L

Androgen receptor (AR)

Curcumin can suppress apoptosis and proliferation of endometrial cancer cells through decreasing expression of androgen receptor

NA

[34]

112.5 μM

-

Curcumin has an antiproliferative effect on MCF-7, MG-63 and MDA-MB-231 cells

MDA-MB-231

MCF-7

MG-63

[40]

Curcumin loaded amphiphilic mixed micelles

10 μM

Survivin

Bcl-2

PARP

Inhibition of tumor growth,

Apoptosis induction

Ishikawa

[41]

Liposomal Curcumin

NA

NF-κB

Inhibition of tumor growth

Ishikawa

HEC-1

[42]

Curcumin Phytosome

2 g/day

-

Immunomodulatory effects

-

[43]